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dc.contributor.authorField, Des*
dc.contributor.authorSeisling, Nynke*
dc.contributor.authorCotter, Paul D.*
dc.contributor.authorRoss, R Paul*
dc.contributor.authorHill, Colin*
dc.date.accessioned2017-08-29T08:16:01Z
dc.date.available2017-08-29T08:16:01Z
dc.date.issued26/10/2016
dc.identifier.citationField D, Seisling N, Cotter PD, Ross RP and Hill C (2016) Synergistic Nisin-Polymyxin Combinations for the Control of Pseudomonas Biofilm Formation. Front. Microbiol. 7:1713. doi: 0.3389/fmicb.2016.01713en_GB
dc.identifier.urihttp://hdl.handle.net/11019/1497
dc.descriptionpeer-revieweden_GB
dc.description.abstractThe emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa. The results reveal that the concentrations of polymyxins that are required to effectively inhibit biofilm formation can be dramatically reduced when combined with nisin, thereby enhancing efficacy, and ultimately, restoring sensitivity. Such combination therapy may yield added benefits by virtue of reducing polymyxin toxicity through the administration of significantly lower levels of polymyxin antibiotics.en_GB
dc.description.sponsorshipDF,CH,PC,and RR are supported by the Irish Government under the National Development Plan,through a Science Foundation Ireland(SFI) Technology and Innovation Development Award (TIDA14/TIDA/2286) to DF,a SFI Investigator award to CH and RR(10/IN.1/B3027),SFI-PI funding (11/PI/1137)to PC and the Alimentary Pharmabiotic Centre under Grant Number SFI/12/RC/2273
dc.language.isoenen_GB
dc.publisherFrontiersen_GB
dc.relation.ispartofseriesFrontiers in Microbiology;vol 7
dc.subjectbiofilmen_GB
dc.subjectcolistinen_GB
dc.subjectpolymyxinen_GB
dc.subjectnisinen_GB
dc.subjectlantibioticen_GB
dc.subjectP. aeruginosaen_GB
dc.subjectbacteriocinen_GB
dc.subjectantibioticen_GB
dc.titleSynergistic Nisin-Polymyxin Combinations for the Control of Pseudomonas Biofilm Formationen_GB
dc.typeArticleen_GB
dc.identifier.rmisMDBY-0106-6286
dc.identifier.doihttps://doi.org/10.3389/fmicb.2016.01713
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumberTIDA14/TIDA/2286
dc.contributor.sponsorGrantNumber10/IN.1/B3027
dc.contributor.sponsorGrantNumber11/PI/1137
dc.contributor.sponsorGrantNumberSFI/12/RC/2273
refterms.dateFOA2018-01-12T08:56:53Z


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