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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/231

Title: Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intra-muscular fat content
Authors: Aslan, Ozlem
Sweeney, Torres
Mullen, Anne Maria
Hamill, Ruth M
Keywords: Bovine ankyrin 1 gene
Meat quality
Single Nucleotide Polymorphisms
Haplotypes
Genomic selection
Issue Date: 15-Dec-2010
Publisher: Biomed Central
Citation: Ozlem Aslan, Torres Sweeney, Anne M Mullen and Ruth M Hamill. Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intramuscular fat content. BMC Genetics 2010, 11:111. DOI:10.1186/1471-2156-11-111
Series/Report no.: BMC Genetics
Abstract: Recent QTL and gene expression studies have highlighted ankyrins as positional and functional candidate genes for meat quality. Our objective was to characterise the promoter region of the bovine ankyrin 1 gene and to test polymorphisms for association with sensory and technological meat quality measures. Results Seven novel promoter SNPs were identified in a 1.11 kb region of the ankyrin 1 promoter in Angus, Charolais and Limousin bulls (n = 15 per breed) as well as 141 crossbred beef animals for which meat quality data was available. Eighteen haplotypes were inferred with significant breed variation in haplotype frequencies. The five most frequent SNPs and the four most frequent haplotypes were subsequently tested for association with sensory and technological measures of meat quality in the crossbred population. SNP1, SNP3 and SNP4 (which were subsequently designated regulatory SNPs) and SNP5 were associated with traits that contribute to sensorial and technological measurements of tenderness and texture; Haplotype 1 and haplotype 4 were oppositely correlated with traits contributing to tenderness (P < 0.05). While no single SNP was associated with intramuscular fat (IMF), a clear association with increased IMF and juiciness was observed for haplotype 2. Conclusion The conclusion from this study is that alleles defining haplotypes 2 and 4 could usefully contribute to marker SNP panels used to select individuals with improved IMF/juiciness or tenderness in a genome-assisted selection framework.
Description: peer-reviewed
URI: http://hdl.handle.net/11019/231
http://dx.doi.org/10.1186/1471-2156-11-111
Appears in Collections:Teagasc publications in Biomed Central
Food Chemistry & Technology
Food Quality & Sensory Science

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