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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/267

Title: Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations
Authors: Bermingham, Mairead L
Brotherstone, Susan
Berry, Donagh P.
More, Simon J
Good, Margaret
Cromie, Andrew R
White, Ian MS
Higgins, Isabella
Coffey, Mike
Downs, Sara H
Glass, Elizabeth J
Bishop, Stephen C
Mitchell, Andy P
Clifton-Hadley, Richard S
Woolliams, John A
Keywords: Bovine tuberculosis
Holstein-Friesian
Epidemiology
Issue Date: 3-Jun-2011
Publisher: Biomed Central
Citation: Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations. Bermingham, Mairead L. et al. BMC Proceedings, 2011, 5(Suppl 4):S15. doi:10.1186/1753-6561-5-S4-S15
Series/Report no.: BMC Proceedings
Abstract: Background: Here, we jointly summarise scientific evidence for genetic variation in resistance to infection with Mycobacterium bovis, the primary agent of bovine tuberculosis (TB), provided by two recent and separate studies of Holstein-Friesian dairy cow populations in Great Britain (GB) and Ireland. Methods: The studies quantified genetic variation within archived data from field and abattoir surveillance control programmes within each country. These data included results from the single intradermal comparative tuberculin test (SICTT), abattoir inspection for TB lesions and laboratory confirmation of disease status. Threshold animal models were used to estimate variance components for responsiveness to the SICTT and abattoir confirmed M. bovis infection. The link functions between the observed 0/1 scale and the liability scale were the complementary log-log in the GB, and logit link function in the Irish population. Results and discussion: The estimated heritability of susceptibility to TB, as judged by responsiveness to the SICTT, was 0.16 (0.012) and 0.14 (0.025) in the GB and Irish populations, respectively. For abattoir or laboratory confirmation of infection, estimates were 0.18 (0.044) and 0.18 (0.041) from the GB and the Irish populations, respectively. Conclusions: Estimates were all significantly different from zero and indicate that exploitable variation exists among GB and Irish Holstein Friesian dairy cows for resistance to TB. Epidemiological analysis suggests that factors such as variation in exposure or imperfect sensitivity and specificity would have resulted in underestimation of the true values.
Description: peer-reviewed
URI: http://hdl.handle.net/11019/267
http://dx.doi.org/10.1186/1753-6561-5-S4-S15
Appears in Collections:Animal & Bioscience
Teagasc publications in Biomed Central

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