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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/286

Title: Follicle stimulating hormone isoforms and plasma concentrations of estradiol and inhibin A in dairy cows with ovulatory and non-ovulatory follicles during the first postpartum follicle wave
Authors: Butler, Stephen T.
Pelton, Susanne H.
Knight, Phillip G.
Butler, W.R.
Keywords: FSH isoforms
Ovulation
Estradiol
Inhibin A
Dairy cow
Issue Date: Jul-2008
Publisher: Elsevier Science Inc.
Citation: Stephen T. Butler, Susanne H. Pelton, Phillip G. Knight, W.R. Butler. Follicle-stimulating hormone isoforms and plasma concentrations of estradiol and inhibin A in dairy cows with ovulatory and non-ovulatory follicles during the first postpartum follicle wave. Domestic Animal Endocrinology, 35(1), July 2008:112–119. DOI:10.1016/j.domaniend.2008.03.002
Series/Report no.: Domestic Animal Endocrinology;vol. 35
Abstract: Following parturition, all cows display a wave of ovarian follicular growth, but a large proportion fail to generate a preovulatory rise in estradiol, and hence fail to ovulate. Follicle stimulating hormone (FSH) exists as multiple isoforms in the circulation depending on the type and extent of glycosylation, and this has pronounced effects on its biological properties. This study examined differences in plasma FSH, estradiol, and inhibin A concentrations, and the distribution of FSH isoforms in cows with ovulatory or atretic dominant follicles during the first postpartum follicle wave. Plasma FSH isoform distribution was examined in both groups during the period of final development of the dominant follicle by liquid phase isoelectric focusing. Cows with an ovulatory follicle had higher circulating estradiol and inhibin A concentrations, and lower plasma FSH concentrations. The distribution of FSH isoforms displayed a marked shift toward the less acidic isoforms in cows with ovulatory follicles. A higher proportion of the FSH isoforms had a pI >5.0 in cows with ovulatory follicles compared to those with atretic follicles. In addition, cows with ovulatory follicles had greater dry matter intake, superior energy balance, elevated circulating concentrations of insulin and insulin-like growth factor-I, and lower plasma nonesterified fatty acids. The shift in FSH isoforms toward a greater abundance of the less acidic isoforms appears to be a key component in determining the capability for producing a preovulatory rise in estradiol, and this shift in FSH isoforms was associated with more favorable bioenergetic and metabolic status.
Description: Peer-reviewed.
This is the author’s version of a work that was accepted for publication in Domestic Animal Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Domestic Animal Endocrinology, 35(1), July 2008. DOI: 10.1016/j.domaniend.2008.03.002
URI: http://hdl.handle.net/11019/286
http://dx.doi.org/10.1016/j.domaniend.2008.03.002
http://www.sciencedirect.com/science/article/pii/S0739724008000283
ISSN: 0739-7240
Appears in Collections:Animal & Bioscience

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