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|Title: ||A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle|
|Authors: ||Finlay, Emma K.|
Berry, Donagh P.
Gormley, Eamonn P.
Bradley, Daniel G
|Keywords: ||Bovine Tuberculosis|
Taurine transporter gene SLC6A6
|Issue Date: ||Feb-2012|
|Citation: ||Finlay EK, Berry DP, Wickham B, Gormley EP, Bradley DG (2012) A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle. PLoS ONE 7(2): e30545. doi:10.1371/journal.pone.0030545|
|Series/Report no.: ||PLoS One;|
|Abstract: ||Background: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although
many factors influence infection and progression of the disease, there is a host genetic component and dissection of this
may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of
infection presents a noisy signal for genomewide association study.
Methodology/Principal Findings: We calculated a composite phenotype of genetic merit for TB susceptibility based on
disease incidence in daughters of elite sires used for artificial insemination in the Irish dairy herd. This robust measure was
compared with 44,426 SNP genotypes in the most informative 307 subjects in a genome wide association analysis. Three
SNPs in a 65 kb genomic region on BTA 22 were associated (i.e. p,1025, peaking at position 59588069, p = 4.0261026) with
Conclusions/Significance: A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it
contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not
previously been investigated for its role in tuberculosis infection.|
|Appears in Collections:||Animal & Bioscience|
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