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|Title: ||Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression|
|Authors: ||Beecher, Christine|
Berry, Donagh P.
Meaney, William J
McCarthy, Tommie V.
Ross, R Paul
|Issue Date: ||18-May-2009|
|Publisher: ||Cambridge University Press: Published for the Institute of Food Research and the Hannah Research Institute|
|Citation: ||Christine Beecher, Mairéad Daly, Donagh P Berry, Katja Klostermann, James Flynn, William Meaney, Colin Hill, Tommie V McCarthy, R Paul Ross and Linda Giblin (2009). Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression. Journal of Dairy Research, 76, pp 340-348. doi:10.1017/S0022029909004154.Copyright © Proprietors of Journal of Dairy Research|
|Series/Report no.: ||Journal of Dairy Research;vol 76|
|Abstract: ||Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials,
that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary
gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post
infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1b and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response.|
|Appears in Collections:||Animal & Bioscience|
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