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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/426

Title: Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression
Authors: Beecher, Christine
Daly, Mairead
Berry, Donagh P.
Klostermann, Katja
Flynn, James
Meaney, William J
Hill, Colin
McCarthy, Tommie V.
Ross, R Paul
Giblin, Linda
Keywords: Mastitis
Lactococcus lactis
Probiotic treatment
Issue Date: 18-May-2009
Publisher: Cambridge University Press: Published for the Institute of Food Research and the Hannah Research Institute
Citation: Christine Beecher, Mairéad Daly, Donagh P Berry, Katja Klostermann, James Flynn, William Meaney, Colin Hill, Tommie V McCarthy, R Paul Ross and Linda Giblin (2009). Administration of a live culture of Lactococcus lactis DPC 3147 into the bovine mammary gland stimulates the local host immune response, particularly IL-1β and IL-8 gene expression. Journal of Dairy Research, 76, pp 340-348. doi:10.1017/S0022029909004154.Copyright © Proprietors of Journal of Dairy Research
Series/Report no.: Journal of Dairy Research;vol 76
Abstract: Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1b and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response.
Description: peer-reviewed
URI: http://hdl.handle.net/11019/426
http://dx.doi.org/10.1017/S0022029909004154
http://journals.cambridge.org/article_S0022029909004154
ISSN: 1469-7629
Appears in Collections:Animal & Bioscience
Food Biosciences

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