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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/485

Title: The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes
Authors: Fares, Mario A
Keane, Orla M
Toft, Christina
Carretero-Paulet, Lorenzo
Jones, Gary W
Keywords: Gene duplication
Whole-genome duplications
Small-scale duplications
Saccharomyces cerevisiae genome
Issue Date: 3-Jan-2013
Publisher: PLoS
Citation: Fares MA, Keane OM, Toft C, Carretero-Paulet L, and Jones GW. 2013. The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes. PLoS Genetics 9 (1): e1003176. doi:10.1371/journal.pgen.1003176
Series/Report no.: PLoS Genetics;vol 9
Abstract: Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGDduplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their subcellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD–duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplication
Description: peer-reviewed
This study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitness was supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship (EMBO ALTF 730-2011).
URI: http://hdl.handle.net/11019/485
http://dx.doi.org/10.1371/journal.pgen.1003176
ISSN: 1553-7390
Appears in Collections:Animal & Bioscience

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