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Please use this identifier to cite or link to this item: http://hdl.handle.net/11019/577

Title: Beneficial modulation of the gut microbiota
Authors: Walsh, Calum J.
Guinane, Caitriona M.
O'Toole, Paul W.
Cotter, Paul D.
Keywords: Microbiota
Gut Health
Microbial modulation
Faecal microbiota transplantation
Diet
Antimicrobial
Issue Date: 26-Mar-2014
Publisher: Elsevier
Citation: Calum J. Walsh, Caitriona M. Guinane, Paul W. O’Toole, Paul D. Cotter, Beneficial modulation of the gut microbiota, FEBS Letters, Available online 26 March 2014, http://dx.doi.org/10.1016/j.febslet.2014.03.035.
Series/Report no.: FEBS Letters;
Abstract: The human gut microbiota comprises approximately 100 trillion microbial cells and has a significant effect on many aspects of human physiology including metabolism, nutrient absorption and immune function. Disruption of this population has been implicated in many conditions and diseases, including examples such as obesity, inflammatory bowel disease and colorectal cancer that are highlighted in this review. A logical extension of these observations suggests that the manipulation of the gut microbiota can be employed to prevent or treat these conditions. Thus, here we highlight a variety of options, including the use of changes in diet (including the use of prebiotics), antimicrobial-based intervention, probiotics and faecal microbiota transplantation, and discuss their relative merits with respect to modulating the intestinal community in a beneficial way.
Description: peer-reviewed
C.J.W, C.M.G. and P.D.C are supported by a SFI PI award “Obesibiotics” (11/PI/1137)
URI: http://hdl.handle.net/11019/577
http://dx.doi.org/10.1016/j.febslet.2014.03.035
http://www.sciencedirect.com/science/article/pii/S0014579314002543
ISSN: 0014-5793
Appears in Collections:Food Biosciences

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