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Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions
Gallagher, Louise Smith, Alanna Kavanagh, Kevin Devereux, Michael Colleran, John Breslin, Carmel Richards, Karl G. McCann, Malachy Rooney, A. Denise
Gallagher, Louise
Smith, Alanna
Kavanagh, Kevin
Devereux, Michael
Colleran, John
Breslin, Carmel
Richards, Karl G.
McCann, Malachy
Rooney, A. Denise
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2021-06-14
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Gallagher L, Smith A, Kavanagh K, et al. Preparation and Antimicrobial Properties of Alginate and Serum Albumin/Glutaraldehyde Hydrogels Impregnated with Silver(I) Ions. Chemistry 2021;3(2):672-86. doi: https://doi.org/10.3390/chemistry3020047
Abstract
Calcium alginate (CaALG) hydrogel beads and two sets of composite beads, formed from
a combination of calcium alginate/propylene glycol alginate/human serum albumin (CaALG/PGA/
HSA) and from calcium alginate with the quaternary ammonium salt, (3-(trimethoxysilyl)propyl)-
octadecyldimethylammonium chloride (QA), (CaALG/QA), were prepared. Bovine serum albumin
(BSA) was condensed with glutaraldehyde (GLA) to form a BSA/GLA hydrogel. The corresponding
Ag+-containing gels of all of the above hydrogels were also formed, and slow leaching of the biocidal
transition metal ion from the gels bestowed broad spectrum antimicrobial activity. In the absence
of added Ag+, CaALG/QA was the only material to deliver marginal to moderate antibacterial
and antifungal effects. The Ag+ impregnated hydrogel systems have the potential to maintain the
antimicrobial properties of silver, minimising the risk of toxicity, and act as reservoirs to afford
ongoing sterility.