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Bacteriocin production: a relatively unharnessed probiotic trait?
Hegarty, James W. Guinane, Caitriona M. Paul Ross, R. Hill, Colin Cotter, Paul D.
Hegarty, James W.
Guinane, Caitriona M.
Paul Ross, R.
Hill, Colin
Cotter, Paul D.
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2016-10-27
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Hegarty JW, Guinane CM, Ross RP et al. Bacteriocin production: a relatively unharnessed probiotic trait? [version 1; peer review: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):2587 (https://doi.org/10.12688/f1000research.9615.1)
Abstract
Probiotics are “live microorganisms which, when consumed in adequate amounts, confer a health benefit to the host”. A number of attributes are highly sought after among these microorganisms, including immunomodulation, epithelial barrier maintenance, competitive exclusion, production of short-chain fatty acids, and bile salt metabolism. Bacteriocin production is also generally regarded as a probiotic trait, but it can be argued that, in contrast to other traits, it is often considered a feature that is desirable, rather than a key probiotic trait. As such, the true potential of these antimicrobials has yet to be realised.