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Lactobacillus acidophilus JCM 1132 Strain and Its Mutant with Different Bacteriocin-Producing Behaviour Have Various In Situ Effects on the Gut Microbiota of Healthy Mice

Wang, Gang
; 
Yu, Yunxia
; 
Garcia-Gutierrez, Enriqueta
; 
Jin, Xing
; 
He, Yufeng
; 
Wang, Linlin
; 
Tian, Peijun
; 
Liu, Zhenmin
; 
Zhao, Jianxin
; 
Zhang, Hao
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Keywords
Lactobacillus acidophilus, bacteriocin, short-chain fatty acids, gut microbiota, in situ effects
Date
2019-12-25
Collections
Food Biosciences
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URI
http://hdl.handle.net/11019/2557
Citation
Wang, G.; Yu, Y.; Garcia-Gutierrez, E.; Jin, X.; He, Y.; Wang, L.; Tian, P.; Liu, Z.; Zhao, J.; Zhang, H.; Chen, W. Lactobacillus acidophilus JCM 1132 Strain and Its Mutant with Different Bacteriocin-Producing Behaviour Have Various In Situ Effects on the Gut Microbiota of Healthy Mice. Microorganisms 2020, 8, 49. https://doi.org/10.3390/microorganisms8010049
Abstract
The production of bacteriocin is considered to be a probiotic trait of lactic acid bacteria (LAB). However, not all strains of LAB harbour bacteriocin genes, even within the same species. Moreover, the effects of bacteriocins on the host gut microbiota and on host physiological indicators are rarely studied. This study evaluated the effects of the bacteriocin-producing Lactobacillus acidophilus strain JCM1132 and its non-producing spontaneous mutant, L. acidophilus CCFM720, on the physiological statuses and gut microbiota of healthy mice. Mice that received the bacteriocin-producing strain JCM1132 exhibited reduced water and food intake. Furthermore, the administration of these strains induced significant changes in the compositional abundance of faecal microbiota at the phylum and genus levels, and some of these changes were more pronounced after one week of withdrawal. The effects of CCFM720 treatment on the gut microbiota seemed to favour the prevention of metabolic diseases to some extent. However, individuals that received JCM1132 treatment exhibited weaker inflammatory responses than those that received CCFM720 treatment. Our results indicate that treatment with bacteriocin-producing or non-producing strains can have different effects on the host. Accordingly, this trait should be considered in the applications of LAB.
Funder
National Natural Science Foundation of China
Priority Academic Program Development of Jiangsu Higher Education Institutions
The Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
Natural Science Foundation of Jiangsu Province
China Postdoctoral Science Foundation
Postdoctoral Science Foundation of Jiangsu Province
Teagasc Walsh Fellowship Programme
Grant Number
31671839
31530056
31301407
JUSRP51501
JUFSTR20180102
BK20180613
2018M642164
2018K090C
2015066
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