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Gene co-expression networks contributing to variation in residual feed intake in bovine hepatic tissue.
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Abstract
Gene co-expression network analyses were performed on hepatic transcriptome data of two breed types
(Charolais (CH) and Holstein-Friesian (HF)), divergent for feed efficiency status through measurement
of residual feed intake (RFI). The relationship between co-expressed genes and RFI was further assessed
through correlation of co-expression networks with trait data including RFI, average daily gain (ADG) and
dry matter intake (DMI). Across both breeds examined, one network of co-expressed genes was positively
correlated with DMI (r=0.48, P=0.03), with a tendency also identified between the same network and RFI
(r=0.42, P=0.07). Functional annotation of genes within this network revealed enrichment (P<0.05) of
pathways related to both amino acid and fatty acid metabolism. Our results suggest a role for these processes
in the hepatic tissue of cattle divergent for RFI. Moreover, genes within this network may represent potential
biomarkers for the selection of improved feed efficiency in cattle across varying breed types.