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Fortified Fermented Rice-Acid Can Regulate the Gut Microbiota in Mice and Improve the Antioxidant Capacity

Liu, Na
; 
Qin, Likang
; 
Lu, Xiafen
; 
Zhao, Yuxuan
; 
Miao, Song
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Keywords
fortified fermentation 1;, Lactobacillus paracasei H4-11 2, ; Kluyveromyces marxianus L1-1 3, gut microbiota 4, anti-oxidation 5
Date
2021-11-24
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Food Chemistry & Technology
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http://hdl.handle.net/11019/3041
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Liu, N.; Qin, L.; Lu, X.; Zhao, Y.; Miao, S. Fortified Fermented Rice-Acid Can Regulate the Gut Microbiota in Mice and Improve the Antioxidant Capacity. Nutrients 2021, 13, 4219. https://doi.org/10.3390/nu13124219
Abstract
The study aimed to explore the effects of fortified fermented rice-acid on the antioxidant capacity of mouse serum and the gut microbiota. Hair characteristics, body mass index, intestinal villus height, intestinal crypt depth, serum antioxidant capacity, and gut microbiota of mice were first measured and the correlation between the antioxidant capacity of mouse serum and the gut microbiota was then explored. The mice in the lactic acid bacteria group (L-group), the mixed bacteria group (LY-group), and the rice soup group (R-group) kept their weight well and had better digestion. The mice in the L-group had the better hair quality (dense), but the hair quality in the R-group and the yeast group (Y-group) was relatively poor (sparse). In addition, the inoculation of Lactobacillus paracasei H4-11 (L. paracasei H4-11) and Kluyveromyces marxianus L1-1 (K. marxianus L1-1) increased the villus height/crypt depth of the mice (3.043 ± 0.406) compared to the noninoculation group (R-group) (2.258 ± 0.248). The inoculation of L. paracasei H4-11 and K. marxianus L1-1 in fermented rice-acid enhanced the blood antioxidant capacity of mouse serum (glutathione 29.503 ± 6.604 umol/L, malonaldehyde 0.687 ± 0.125 mmol/L, catalase 15.644 ± 4.618 U/mL, superoxide dismutase 2.292 ± 0.201 U/mL). In the gut microbiota of L-group and LY-group, beneficial microorganisms (Lactobacillus and Blautia) increased, but harmful microorganisms (Candidatus Arthromitus and Erysipelotrichales) decreased. L. paracasei H4-11 and K. marxianus L1-1 might have a certain synergistic effect on the improvement in antibacterial function since they reduced harmful microorganisms in the gut microbiota of mice. The study provides the basis for the development of fortified fermented rice-acid products for regulating the gut microbiota and improving the antioxidant capacity.
Funder
National Natural Science Foundation of China (32060530), Technology platform and talent team plan of Guizhou. China ((2018)5251), Graduate Research Fund Project of Guizhou (YJSCXJH(2019)028). Industry-University-Research Cooperation Project of Guizhou University (701/700465172217) and China Scholarship Council (201906670006).
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