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Hydrogel-based Bio-nanomachine Transmitters for Bacterial Molecular Communications
Martins, Daniel P. O'Reilly, Huong Q. Coffey, Lee Cotter, Paul D. Balasubramaniam, Sasitharan
Martins, Daniel P.
O'Reilly, Huong Q.
Coffey, Lee
Cotter, Paul D.
Balasubramaniam, Sasitharan
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2020-11-16
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Martins, D. P. and O'Reilly, H. Q. and Coffey, L. and Cotter, P. D. and Balasubramaniam, S. (2020) Hydrogel-Based Bio-Nanomachine Transmitters for Bacterial Molecular Communications. In: Proceedings of the 1st ACM International Workshop on Nanoscale Computing, Communication, and Applications. https://doi.org/10.1145/3416006.3431271
Abstract
Bacterial quorum sensing can be engineered with a view to the
design of biotechnological applications based on their intrinsic role
as a means of communication. We propose the creation of a positive feedback loop that will promote the emission of a superfolded
green fluorescence protein from a bacterial population that will flow
through hydrogel, which is used to encapsulate the cells. These
engineered cells are heretofore referred to as bio-nanomachine
transmitters and we show that for lower values of diffusion coefficient, a higher molecular output signal power can be produced,
which supports the use of engineered bacteria contained within
hydrogels for molecular communications systems. In addition, our
wet lab results show the propagation of the molecular output signal,
proving the feasibility of engineering a positive feedback loop to create a bio-nanomachine transmitter that can be used for biosensing
applications.