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Metabolic phenotyping of the human microbiome

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Keywords
microbiome, metagenomics, metabolomics, short chain fatty acids, bile acids
Date
2019-11-19
Collections
Food Biosciences
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URI
http://hdl.handle.net/11019/2663
Citation
Barton W, O'Sullivan O and Cotter PD. Metabolic phenotyping of the human microbiome [version 1; peer review: 2 approved]. F1000Research 2019, 8(F1000 Faculty Rev):1956 https://doi.org/10.12688/f1000research.19481.1
Abstract
The human microbiome has been identified as having a key role in health and numerous diseases. Trillions of microbial cells and viral particles comprise the microbiome, each representing modifiable working elements of an intricate bioactive ecosystem. The significance of the human microbiome as it relates to human biology has progressed through culture-dependent (for example, media-based methods) and, more recently, molecular (for example, genetic sequencing and metabolomic analysis) techniques. The latter have become increasingly popular and evolved from being used for taxonomic identification of microbiota to elucidation of functional capacity (sequencing) and metabolic activity (metabolomics). This review summarises key elements of the human microbiome and its metabolic capabilities within the context of health and disease.
Funder
Science Foundation Ireland
Department of Agriculture, Food and the Marine
Grant Number
SFI/12/RC/2273
11/PI/1137
13/SIRG/2160
16/RC/3835
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