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Investigation of Intestinal Atresia in a Jersey Sire Family
Carthy, T.R. Keane, O.M. Hanrahan, J.P. Matthews, D. McEwan, J. Rowe, S. Mee, J.
Carthy, T.R.
Keane, O.M.
Hanrahan, J.P.
Matthews, D.
McEwan, J.
Rowe, S.
Mee, J.
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2022
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Carthy, T.R.; Keane, O.M.; Hanrahan, J.P.; Matthews, D.; McEwan, J.; Rowe, S. and Mee, J. (2022). Investigation of Intestinal Atresia in a Jersey Sire Family, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP), pp2810 - 2813
Abstract
Intestinal atresia is a congenital defect resulting in calf mortality within a few days of birth.
This study focuses on two half-sibling Jersey sires who were identified as having a high
proportion of their progeny exhibiting atresia from a longitudinal study of 39 dairy herds over
an 8 year period. The objective of this study was to investigate the genetic cause of intestinal
atresia within this family. Phased high-density genotypes of the two half-sibling sires were used
to identify if common haplotypes were inherited by all affected animals. Whether or not the
paternal haplotype that was inherited by the affected animal at a given locus deviated from the
expectation was tested. A total of 16 SNPs were significantly overrepresented, 14 located in
one region on chromosome 14 and the remaining 2 located in one region on chromosome 26.