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Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients
Ge, Huifang Lin, Peixuan Luo, Taiduan Yan, Zhiming Xiao, Jianbo Miao, Song Chen, Jichen
Ge, Huifang
Lin, Peixuan
Luo, Taiduan
Yan, Zhiming
Xiao, Jianbo
Miao, Song
Chen, Jichen
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2020-07
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H Ge, P Lin, T Luo, Z Yan, J Xiao, S Miao, J Chen, Fabrication of Ligusticum chuanxiong polylactic acid microspheres: A promising way to enhance the hepatoprotective effect on bioactive ingredients, Food Chemistry, 2020, 317, 126377. doi: https://doi.org/10.1016/j.foodchem.2020.126377
Abstract
Ligusticum chuanxiong extract-polylactic acid sustained-release microspheres (LCE-PLA) are fabricated in this study for enhancing both duration and hepatoprotective efficacy of the main bioactive ingredients. LCE-PLA in vitro release, cytotoxicity and in vivo hepatoprotective effect were discussed to evaluate its efficiency and functionality. Results demonstrated that the optimal drug-loading rate and encapsulation efficiency of tetramethylpyrazine (TMP, the main active ingredient) were 8.19%, 83.72%, respectively. The LCE-PLA in vitro release of TMP showed prolong 5-fold and in vitro cytotoxicity declined 25.00% compared with naked LCE. After 6 weeks of in vivo intervention in high fat diet mice, both liver aspartate aminotransferase and alanine aminotransferase levels were higher in LCE-PLA group than LCE group. The above results indicated that TMP had a higher bioavailability of hepatoprotection when encapsulation of LCE-PLA was applied. The current study has provided a promising novel way to enhance the efficacy of short half-life ingredients.