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Effect of passive transfer status on response to a glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) and bovine respiratory syncytial virus (BRSV) vaccine and weaning stress in pre-weaned dairy calves
Dunn, Amanda Welsh, Michael Gordon, Alan Arguello, Anastasio Morrison, Steven J. Earley, Bernadette
Dunn, Amanda
Welsh, Michael
Gordon, Alan
Arguello, Anastasio
Morrison, Steven J.
Earley, Bernadette
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2018-01-09
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Amanda Dunn, Michael Welsh, Alan Gordon, Anastasio Arguello, Steven J. Morrison & Bernadette Earley (2018) Effect of passive transfer status on response to a glycoprotein E (gE)-negative bovine herpesvirus type 1 (BoHV-1) and bovine respiratory syncytial virus (BRSV) vaccine and weaning stress in pre-weaned dairy calves, Journal of Applied Animal Research, 46:1, 907-914, DOI: 10.1080/09712119.2017.1422257
Abstract
The study objectives were to: 1) examine how calves of divergent immune status respond to BRSV
vaccination at 3 weeks of age; 2) trace glycoprotein E negative BoHV-1 antibodies from vaccinated
dams to calf sera and to investigate how passive transfer affects response to live BoHV-1 vaccine at 6
weeks of age; 3) explore the impact of passive transfer status on blood metabolites around weaning.
Thirty seven Holstein cows and their calves were included in the study. All cows were immunised with
a commercial marker vaccine against BoHV-1(gE-) administered intra-muscularly at 4 month prior to
the start of calving. Calves were assigned to 1 of 2 colostrum treatment groups: 1) 5% of BW in
colostrum fed at birth, or 2) 10% of BW in colostrum fed at birth. Calves were also immunised at 3
weeks of age with a respiratory commercial vaccine, and a booster administered 4 weeks later. Calves
were also immunised against BoHV-1 at 6 weeks of age, using one dose of a live commercial vaccine.
The results demonstrated that level of passive immunity had no effect on immune response to
vaccination and the importance of feeding colostrum from vaccinated BoHV-1 gE- dams to provide
calves with passive protection against IBRV.