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Effects of husbandry and low-dose lipopolysaccharide challenge on the acute phase response of young pigs
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2006-02-01
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Llamas Moya, S., Boyle, L., Arkins, S., Lynch, P.B. Effects of husbandry and low-dose lipopolysaccharide challenge on the acute phase response of young pigs, End of Project Reports, Teagasc, 2006.
Abstract
The objectives of this project were to investigate:
• the levels of pro-inflammatory cytokines and major porcine acute phase proteins during the first week of life of pigs; and the effect of the mentioned husbandry practices on possible age-related changes in these immunomodulators.
• the effect of two methods of teeth resection and leaving the teeth intact of the skin temperature of piglets; and the impact of these teeth resection alternatives on the acute phase protein response after resection and at weaning.
• the behavioural and physiological reactions of 5-day-old piglets after surgical castration.
• the acute phase response elicited by low-dose LPS challenge, establishing the time-response of cytokines and acute phase proteins in both the plasma and saliva of pigs; and possible gender differences in the acute phase response in the early postweaning period.
• the effect of surgical castration of 5-day-old pigs on subsequent behavioural, endocrine and immune responses elicited by low-dose LPS challenge in pigs after weaning.