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Things Are Getting Hairy: Enterobacteria Bacteriophage vB_PcaM_CBB
Buttimer, Colin Hendrix, Hanne Oliveira, Hugo Casey, Aidan Neve, Horst McAuliffe, Olivia Ross, R. Paul Hill, Colin Noben, Jean-Paul O'Mahony, Jim
Buttimer, Colin
Hendrix, Hanne
Oliveira, Hugo
Casey, Aidan
Neve, Horst
McAuliffe, Olivia
Ross, R. Paul
Hill, Colin
Noben, Jean-Paul
O'Mahony, Jim
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2017-01-24
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Buttimer C, Hendrix H, Oliveira H, Casey A, Neve H, McAuliffe O, Ross RP, Hill C, Noben J-P, O’Mahony J, Lavigne R and Coffey A (2017) Things Are Getting Hairy: Enterobacteria Bacteriophage vB_PcaM_CBB. Front. Microbiol. 8:44. doi: 10.3389/fmicb.2017.00044
Abstract
Enterobacteria phage vB_PcaM_CBB is a “jumbo” phage belonging to the family
Myoviridae. It possesses highly atypical whisker-like structures along the length of its
contractile tail. It has a broad host range with the capability of infecting species of
the genera Erwinia, Pectobacterium, and Cronobacter. With a genome of 355,922 bp,
excluding a predicted terminal repeat of 22,456 bp, phage CBB is the third largest phage
sequenced to date. Its genome was predicted to encode 554 ORFs with 33 tRNAs.
Based on prediction and proteome analysis of the virions, 29% of its predicted ORFs
could be functionally assigned. Protein comparison shows that CBB shares between
33–38% of its proteins with Cronobacter phage GAP32, coliphages PBECO4 and
121Q as well as Klebsiella phage vB_KleM_Rak2. This work presents a detailed and
comparative analysis of vB_PcaM_CBB of a highly atypical jumbo myoviridae phage,
contributing to a better understanding of phage diversity and biology.