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Heterologous Expression of Biopreservative Bacteriocins With a View to Low Cost Production
Mesa-Pereira, Beatriz Rea, Mary C. Cotter, Paul D. Hill, Colin Ross, R. Paul
Mesa-Pereira, Beatriz
Rea, Mary C.
Cotter, Paul D.
Hill, Colin
Ross, R. Paul
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2018-07-26
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Mesa-Pereira B, Rea MC, Cotter PD, Hill C and Ross RP (2018) Heterologous Expression of Biopreservative Bacteriocins With a View to Low Cost Production. Front. Microbiol. 9:1654. doi: 10.3389/fmicb.2018.01654
Abstract
Bacteriocins, a heterogenous group of antibacterial ribosomally synthesized peptides,
have potential as bio-preservatives in in a wide range of foods and as future therapeutics
for the inhibition of antibiotic-resistant bacteria. While many bacteriocins have been
characterized, several factors limit their production in large quantities, a requirement to
make them commercially viable for food or pharma applications. The identification of
new bacteriocins by database mining has been promising, but their potential is difficult
to evaluate in the absence of suitable expression systems. E. coli has been used as a
heterologous host to produce recombinant proteins for decades and has an extensive
set of expression vectors and strains available. Here, we review the different expression
systems for bacteriocin production using this host and identify the most important
features to guarantee successful production of a range of bacteriocins.