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Bioengineering Lantibiotics for Therapeutic Success

Field, Des
; 
Cotter, Paul D.
; 
Hill, Colin
; 
Ross, R Paul
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Keywords
Antimicrobial peptide, Nisin, Mutagenesis, Antibiotic, post-translational modification, bacteriocin, bacterial resistance
Date
2015-11
Collections
Food Biosciences
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fmicb-06-01363.pdf
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URI
http://hdl.handle.net/11019/1065
Citation
Field D, Cotter PD, Hill C and Ross, RP (2015) Bioengineering Lantibiotics for Therapeutic Success. Front. Microbiol. 6:1363doi: 10.3389/fmicb.2015.01363.
Abstract
Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.
Funder
Science Foundation Ireland
Grant Number
TIDA14/TIDA/2286
10/IN.1/B3027
11/PI/1137
SFI/12/RC/2273
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