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Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome
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2019-11-08
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Patterson, E., Ryan, P.M., Wiley, N. et al. Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome. Sci Rep 9, 16323 (2019). https://doi.org/10.1038/s41598-019-51781-x
Abstract
Metabolic and neuroactive metabolite production represents one of the mechanisms through which
the gut microbiota can impact health. One such metabolite, gamma-aminobutyric acid (GABA), can
modulate glucose homeostasis and alter behavioural patterns in the host. We previously demonstrated
that oral administration of GABA-producing Lactobacillus brevis DPC6108 has the potential to increase
levels of circulating insulin in healthy rats. Therefore, the objective of this study was to assess the
efcacy of endogenous microbial GABA production in improving metabolic and behavioural outcomes
in a mouse model of metabolic dysfunction. Diet-induced obese and metabolically dysfunctional
mice received one of two GABA-producing strains, L. brevis DPC6108 or L. brevis DSM32386, daily for
12 weeks. After 8 and 10 weeks of intervention, the behavioural and metabolic profles of the mice
were respectively assessed. Intervention with both L. brevis strains attenuated several abnormalities
associated with metabolic dysfunction, causing a reduction in the accumulation of mesenteric adipose
tissue, increased insulin secretion following glucose challenge, improved plasma cholesterol clearance
and reduced despair-like behaviour and basal corticosterone production during the forced swim test.
Taken together, this exploratory dataset indicates that intervention with GABA-producing lactobacilli
has the potential to improve metabolic and depressive- like behavioural abnormalities associated with
metabolic syndrome in mice.