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dc.contributor.authorRichardson, Ian W.*
dc.contributor.authorBradley, Dan G.*
dc.contributor.authorHiggins, Isabella M.*
dc.contributor.authorMore, Simon J.*
dc.contributor.authorMcClure, Jennifer*
dc.contributor.authorBerry, Donagh P.*
dc.date.accessioned2016-07-05T15:36:15Z
dc.date.available2016-07-05T15:36:15Z
dc.date.issued2014-11-18
dc.identifier.citationRichardson et al. Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle. Genetics Selection Evolution 2014, 46:77. DOI: 10.1186/s12711-014-0077-1.en_GB
dc.identifier.urihttp://hdl.handle.net/11019/1017
dc.identifier.urihttp://dx.doi.org/10.1186/s12711-014-0077-1
dc.descriptionpeer-revieweden_GB
dc.descriptionThis work was supported by Science Foundation Ireland Principal Investigator award grant number 09/IN.1/B2642.
dc.description.abstractBackground Infection of livestock with bovine tuberculosis (bTB; Mycobacterium bovis) is of major economical concern in many countries; approximately 15 000 to 20 000 cattle are infected per year in Ireland. The objective of this study was to quantify the genetic variation for bTB susceptibility in Irish dairy and beef cattle. Methods A total of 105 914 cow, 56 904 heifer and 21 872 steer single intra-dermal comparative tuberculin test records (i.e., binary trait) collected from the years 2001 to 2010 from dairy and beef herds were included in the analysis. Only animal level data pertaining to periods of herd bTB infection were retained. Variance components for bTB were estimated using animal linear and threshold mixed models and co-variances were estimated using sire linear mixed models. Results Using a linear model, the heritability for susceptibility to bTB in the entire dataset was 0.11 and ranged from 0.08 (heifers in dairy herds) to 0.19 (heifers in beef herds) among the sub-populations investigated. Differences in susceptibility to bTB between breeds were clearly evident. Estimates of genetic correlations for bTB susceptibility between animal types (i.e., cows, heifers, steers) were all positive (0.10 to 0.64), yet different from one. Furthermore, genetic correlations for bTB susceptibility between environments that differed in herd prevalence of bTB ranged from 0.06 to 0.86 and were all different from one. Conclusions Genetic trends for bTB susceptibility observed in this study suggest a slight increase in genetic susceptibility to bTB in recent years. Since bTB is of economic importance and because all animals are routinely tested at least once annually in Ireland and some other countries, the presence of genetic variation for bTB susceptibility suggests that bTB susceptibility should be included in a national breeding program to halt possible deterioration in genetic susceptibility to bTB infection.en_GB
dc.description.sponsorshipScience FOundation IRelanden_GB
dc.language.isoenen_GB
dc.publisherBiomed Centralen_GB
dc.relation.ispartofseriesGenetics Selection Evolution;vol 46
dc.subjectMycobacterium bovisen_GB
dc.subjectCattleen_GB
dc.subjectgenetic variation for bTB susceptibilityen_GB
dc.subjectBovine TBen_GB
dc.titleVariance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattleen_GB
dc.typeArticleen_GB
dc.identifier.rmisMKAB-0201-6195
refterms.dateFOA2018-01-12T08:27:37Z


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