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    Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

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    Author
    Marques, T. M.
    Patterson, E.
    Wall, R.
    O'Sullivan, Orla
    Fitzgerald, G. F.
    Cotter, Paul D.
    Dinan, T. G.
    Cryan, J. F.
    Ross, R Paul
    Stanton, Catherine
    Keyword
    streptozotocin
    type-1 diabetes,
    Probiotic
    γ-aminobutyric acid
    Date
    26/05/2016
    
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    URI
    http://hdl.handle.net/11019/1032
    Citation
    T.M. Marques, E. Patterson, R. Wall, O. O’ Sullivan, G.F. Fitzgerald, P.D. Cotter, T.G. Dinan, J.F, Cryan, J.F, Ross, R. P., Stanton, C. Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model. Beneficial Microbes: 7 (3) - Pages: 409 - 420. DOI: http://dx.doi.org/10.3920/BM2015.0154
    Abstract
    The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~109microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and non-diabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or ~109 L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P<0.05), but did not alter other metabolic markers in healthy rats. Diabetes induced by STZ injection decreased body weight (P<0.05), increased intestinal length (P<0.05) and stimulated water and food intake. Insulin was decreased (P<0.05), whereas glucose was increased (P<0.001) in all diabetic groups, compared with non-diabetic controls. A decrease (P<0.01) in glucose levels was observed in diabetic rats receiving L. brevis DPC 6108, compared with diabetic-controls. Both the composition and diversity of the intestinal microbiota were affected by diabetes. Microbial diversity in diabetic rats supplemented with low GABA was not reduced (P>0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 attenuated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.
    Funder
    Science Foundation Ireland
    Grant Number
    SFI/12/RC/2273
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.3920/BM2015.0154
    Scopus Count
    Collections
    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences

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