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dc.contributor.authorSayers, Riona*
dc.contributor.authorSayers, Gearoid*
dc.contributor.authorGraham, David A.*
dc.contributor.authorArkins, S.*
dc.date.accessioned2016-10-19T11:21:17Z
dc.date.available2016-10-19T11:21:17Z
dc.date.issued2015-03-25
dc.identifier.citationRíona G. Sayers, Gearóid P. Sayers, David A. Graham, Sean Arkins, Impact of three inactivated bovine viral diarrhoea virus vaccines on bulk milk p80 (NS3) ELISA test results in dairy herds, The Veterinary Journal, 2015, 205(1), 56-61, DOI: 10.1016/j.tvjl.2015.03.025en_GB
dc.identifier.issn1090-0233
dc.identifier.urihttp://hdl.handle.net/11019/1083
dc.descriptionpeer-revieweden_GB
dc.description.abstractBovine viral diarrhoea virus (BVDV) is endemic in many countries and vaccines are used as a component of control and eradication strategies. Surveillance programmes to detect exposure to BVDV often incorporate the use of bulk milk (BM) testing for antibodies against BVDV p80 (NS3), but vaccination can interfere with these results. The aim of this study was to evaluate whether BVDV vaccines would confound BM testing for specific antibodies in a nationally representative group of commercial dairy farms in the Republic of Ireland. A total of 256 commercial dairy herds were included in the statistical analysis. Quarterly BM or serum samples from selected weanling heifers (unvaccinated homeborn youngstock) were assessed by ELISA for antibodies against the BVDV p80 subunit and whole virus. Wilcoxon ranksum and receiver operating characteristic (ROC) analyses were used to examine differences among groups vaccinated with one of three commercially available inactivated BVDV vaccines. Two of the three vaccines showed evidence of interference with ELISA testing of BM samples. ROC analysis highlighted that one vaccine did not reduce the discriminatory power of the BVDV p80 ELISA for identification of herds with evidence of recent BVDV circulation, when compared with unvaccinated herds; thus, administration of this vaccine would allow uncomplicated interpretation of BM ELISA test results in vaccinated seropositive herds. Seasonal differences in BM antibody results were identified, suggesting that the latter half of lactation is the most suitable time for sampling dairy herds containing predominantly spring calving cows. The results of the present study are likely to prove useful in countries allowing vaccination during or following BVDV eradication, where BM testing is required as part of the surveillance strategy.en_GB
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.ispartofseriesThe Veterinary Journal;vol 2015
dc.subjectDairy cattleen_GB
dc.subjectBovine viral diarrhoea virusen_GB
dc.subjectVaccineen_GB
dc.subjectELISAen_GB
dc.subjectBulk milken_GB
dc.titleImpact of three inactivated bovine viral diarrhoea virus vaccines on bulk milk p80 (NS3) ELISA test results in dairy herdsen_GB
dc.typeArticleen_GB
dc.identifier.rmisMKAB-0204-5900
dc.identifier.doihttp://dx.doi.org/10.1016/j.tvjl.2015.03.025
dc.contributor.sponsorIrish Dairy Levy Research Trust
refterms.dateFOA2018-01-12T08:36:48Z


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