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    Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy

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    Author
    Dalmasso, Marion
    Strain, Ronan
    Neve, Horst
    Franz, C.M.A.P.
    Cousin, Fabien J.
    Ross, R Paul
    Hill, Colin
    Keyword
    Bacteriophages
    Escherichia coli
    Bacterial biofilms
    Viral genomics
    Antibiotics
    Comparative genomics
    Date
    09/06/2016
    
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    URI
    http://hdl.handle.net/11019/1087
    Citation
    Dalmasso M, Strain R, Neve H, Franz CMAP, Cousin FJ, et al. (2016) Three New Escherichia coli Phages from the Human Gut Show Promising Potential for Phage Therapy. PLoS ONE 11(6): e0156773. doi: 10.1371/journal.pone.0156773
    Abstract
    With the emergence of multi-drug resistant bacteria the use of bacteriophages (phages) is gaining renewed interest as promising anti-microbial agents. The aim of this study was to isolate and characterize phages from human fecal samples. Three new coliphages, ɸAPCEc01, ɸAPCEc02 and ɸAPCEc03, were isolated. Their phenotypic and genomic characteristics, and lytic activity against biofilm, and in combination with ciprofloxacin, were investigated. All three phages reduced the growth of E. coli strain DPC6051 at multiplicity of infection (MOI) between 10−3 and 105. A cocktail of all three phages completely inhibited the growth of E. coli. The phage cocktail also reduced biofilm formation and prevented the emergence of phage-resistant mutants which occurred with single phage. When combined with ciprofloxacin, phage alone or in cocktail inhibited the growth of E. coli and prevented the emergence of resistant mutants. These three new phages are promising biocontrol agents for E. coli infections.
    Funder
    Science Foundation Ireland
    Grant Number
    SFI/12/RC/2273
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1371/journal.pone.0156773
    Scopus Count
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    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences

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