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    Early Gut Microbiota Perturbations Following Intrapartum Antibiotic Prophylaxis to Prevent Group B Streptococcal Disease

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    Author
    Mazzola, Giuseppe
    Murphy, Kiera
    Ross, R Paul
    Di Gioia, Diana
    Biavati, Bruno
    Corvaglia, Luigi T.
    Faldella, Giacomo
    STANTON, CATHERINE cc
    Keyword
    Bifidobacterium
    Infants
    Microbiome
    Antibiotic
    Enterobacteriaceae
    Dietary factors
    bacterial diversity
    Date
    22/06/2016
    
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    URI
    http://hdl.handle.net/11019/1089
    Citation
    Mazzola G, Murphy K, Ross RP, Di Gioia D, Biavati B, et al. (2016) Early Gut Microbiota Perturbations Following Intrapartum Antibiotic Prophylaxis to Prevent Group B Streptococcal Disease. PLoS ONE 11(6): e0157527. doi: 10.1371/journal.pone.0157527
    Abstract
    The faecal microbiota composition of infants born to mothers receiving intrapartum antibiotic prophylaxis with ampicillin against group B Streptococcus was compared with that of control infants, at day 7 and 30 of life. Recruited newborns were both exclusive breastfed and mixed fed, in order to also study the effect of dietary factors on the microbiota composition. Massive parallel sequencing of the V3-V4 region of the 16S rRNA gene and qPCR analysis were performed. Antibiotic prophylaxis caused the most marked changes on the microbiota in breastfed infants, mainly resulting in a higher relative abundance of Enterobacteriaceae, compared with control infants (52% vs. 14%, p = 0.044) and mixed-fed infants (52% vs. 16%, p = 0.13 NS) at day 7 and in a lower bacterial diversity compared to mixed-fed infants and controls. Bifidobacteria were also particularly vulnerable and abundances were reduced in breastfed (p = 0.001) and mixed-fed antibiotic treated groups compared to non-treated groups. Reductions in bifidobacteria in antibiotic treated infants were also confirmed by qPCR. By day 30, the bifidobacterial population recovered and abundances significantly increased in both breastfed (p = 0.025) and mixed-fed (p = 0.013) antibiotic treated groups, whereas Enterobacteriaceae abundances remained highest in the breastfed antibiotic treated group (44%), compared with control infants (16%) and mixed-fed antibiotic treated group (28%). This study has therefore demonstrated the short term consequences of maternal intrapartum antibiotic prophylaxis on the infant faecal microbial population, particularly in that of breastfed infants.
    Funder
    Department of Agriculture, Food and the Marine; European Union; Science Foundation Ireland; Global Grant Spinner project 2013; Teagasc Walsh Fellowship Programme
    Grant Number
    INFANTMET 10FDairy; MyNewGut 613979
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1371/journal.pone.0157527
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    Food Biosciences
    Food Biosciences
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