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    Genetic basis of benzimidazole resistance in Teladorsagia circumcincta in Ireland

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    Author
    Keegan, Jason D
    Good, Barbara
    de Waal, Theo
    Fanning, June
    Keane, Orla M
    Keyword
    Sheep
    Anthelmintic
    Resistance
    Benzimidazole
    Teladorsagia
    β-tubulin
    Date
    2017-02-13
    
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    URI
    http://hdl.handle.net/11019/1102
    Citation
    Keegan, Jason D. et al.Genetic basis of benzimidazole resistance in Teladorsagia circumcincta in Ireland. Irish Veterinary Journal. 2017 Feb 13;70(1):8. DOI: 10.1186/s13620-017-0087-8
    Abstract
    Resistance to benzimidazole (BZ) anthelmintics is common in ovine nematodes of economic importance. Single nucleotide polymorphisms (SNP) at three positions in the isotype 1 β– tubulin gene have been associated with BZ resistance and molecular tests for the detection of BZ resistance have been developed. In order to determine if such tests are practicable in Ireland the polymorphisms associated with BZ resistance must be identified. To this end, BZ-resistant nematodes were recovered from four farms in Ireland. Resistant Teladorsagia circumcincta, Cooperia curticei and Trichostrongylus colubriformis were recovered, with resistant T. circumcincta the most common and the only species studied further. Sequencing of the isotype 1 β–tubulin gene from resistant T. circumcincta identified a T - A transition, resulting in an F200Y substitution known to be responsible for BZ-resistance, on three of the farms. However, on the fourth farm the frequency of the resistant A allele was only 0.33 indicating another BZ resistance mechanism may be present on this farm. An additional polymorphism resulting in a substitution of glutamate for leucine (E198L) was also found on this farm at low frequency (0.17). No polymorphisms at position 167 were identified on any farm. Therefore, molecular tests to detect BZ resistance in T. circumcincta in Ireland could prove useful; however, they may result in some instances of resistance remaining undetected.
    Funder
    Department of Agriculture, Food and the Marine
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.1186/s13620-017-0087-8
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    Teagasc publications in Biomed Central
    Animal & Bioscience

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