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dc.contributor.authorKelleher, Philip*
dc.contributor.authorBottacini, Francesca*
dc.contributor.authorMahony, Jennifer*
dc.contributor.authorKilcawley, Kieran N*
dc.contributor.authorvan Sinderen, Douwe*
dc.date.accessioned2017-04-24T11:26:20Z
dc.date.available2017-04-24T11:26:20Z
dc.date.issued29/03/2017
dc.identifier.citationKelleher et al. Comparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptation. BMC Genomics. 2017 Mar 29;18(1):267en_GB
dc.identifier.urihttp://hdl.handle.net/11019/1114
dc.descriptionpeer-revieweden_GB
dc.description.abstractBackground Lactococcus lactis is among the most widely studied lactic acid bacterial species due to its long history of safe use and economic importance to the dairy industry, where it is exploited as a starter culture in cheese production. Results In the current study, we report on the complete sequencing of 16 L. lactis subsp. lactis and L. lactis subsp. cremoris genomes. The chromosomal features of these 16 L. lactis strains in conjunction with 14 completely sequenced, publicly available lactococcal chromosomes were assessed with particular emphasis on discerning the L. lactis subspecies division, evolution and niche adaptation. The deduced pan-genome of L. lactis was found to be closed, indicating that the representative data sets employed for this analysis are sufficient to fully describe the genetic diversity of the taxon. Conclusions Niche adaptation appears to play a significant role in governing the genetic content of each L. lactis subspecies, while (differential) genome decay and redundancy in the dairy niche is also highlighted.en_GB
dc.description.sponsorshipPhilip Kelleher is funded by the Department of Agriculture, Food and the Marine under the Food Institutional Research Measure (FIRM) (Ref: 10/RD/TMFRC/704–‘CheeseBoard 2015’ project). Douwe van Sinderen is supported by a Principal Investigator award (Ref. No. 13/IA/1953) through Science Foundation Ireland (SFI). Jennifer Mahony is in receipt of a Technology Innovation Development Award (TIDA) (Ref. No. 14/TIDA/2287) and Starting Investigator Research Grant (15/SIRG/3430) funded by Science Foundation Ireland (SFI).Science Foundation Ireland
dc.description.sponsorshipDepartment of Agriculture, Food and the Marineen_GB
dc.language.isoenen_GB
dc.publisherBiomed Centralen_GB
dc.relation.ispartofseriesBMC Genomics;vol 18
dc.subjectLactococcus lactisen_GB
dc.subjectGenomicsen_GB
dc.subjectSMRT sequencingen_GB
dc.subjectPan-genomeen_GB
dc.subjectNiche adaptationen_GB
dc.titleComparative and functional genomics of the Lactococcus lactis taxon; insights into evolution and niche adaptationen_GB
dc.typeArticleen_GB
dc.date.updated2017-03-29T16:04:05Z
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.identifier.doihttp://dx.doi.org/10.1186/s12864-017-3650-5
dc.contributor.sponsorDepartment of Agriculture, Food and the Marine, Ireland
dc.contributor.sponsorScience Foundation Ireland
dc.contributor.sponsorGrantNumber10/RD/TMFRC/704
dc.contributor.sponsorGrantNumber13/IA/1953
dc.contributor.sponsorGrantNumber14/TIDA/2287
dc.contributor.sponsorGrantNumber15/SIRG/3430
refterms.dateFOA2018-01-12T08:32:53Z


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