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    Synergistic Nisin-Polymyxin Combinations for the Control of Pseudomonas Biofilm Formation

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    Author
    Field, Des
    Seisling, Nynke
    Cotter, Paul D.
    Ross, R Paul
    Hill, Colin
    Keyword
    biofilm
    colistin
    polymyxin
    nisin
    lantibiotic
    P. aeruginosa
    bacteriocin
    antibiotic
    Date
    26/10/2016
    
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    URI
    http://hdl.handle.net/11019/1497
    Citation
    Field D, Seisling N, Cotter PD, Ross RP and Hill C (2016) Synergistic Nisin-Polymyxin Combinations for the Control of Pseudomonas Biofilm Formation. Front. Microbiol. 7:1713. doi: 0.3389/fmicb.2016.01713
    Abstract
    The emergence and dissemination of multi-drug resistant pathogens is a global concern. Moreover, even greater levels of resistance are conferred on bacteria when in the form of biofilms (i.e., complex, sessile communities of bacteria embedded in an organic polymer matrix). For decades, antimicrobial peptides have been hailed as a potential solution to the paucity of novel antibiotics, either as natural inhibitors that can be used alone or in formulations with synergistically acting antibiotics. Here, we evaluate the potential of the antimicrobial peptide nisin to increase the efficacy of the antibiotics polymyxin and colistin, with a particular focus on their application to prevent biofilm formation of Pseudomonas aeruginosa. The results reveal that the concentrations of polymyxins that are required to effectively inhibit biofilm formation can be dramatically reduced when combined with nisin, thereby enhancing efficacy, and ultimately, restoring sensitivity. Such combination therapy may yield added benefits by virtue of reducing polymyxin toxicity through the administration of significantly lower levels of polymyxin antibiotics.
    Funder
    Science Foundation Ireland
    Grant Number
    TIDA14/TIDA/2286; 10/IN.1/B3027; 11/PI/1137; SFI/12/RC/2273
    ae974a485f413a2113503eed53cd6c53
    https://doi.org/10.3389/fmicb.2016.01713
    Scopus Count
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    Food Biosciences
    Food Biosciences
    Food Biosciences
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