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    Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective

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    Author
    Mathur, Harsh
    Field, Des
    Rea, Mary cc
    Cotter, Paul D.
    Hill, Colin
    Ross, R Paul
    Keyword
    bacteriocins
    antibiotic resistance,
    synergy
    stressors
    pathogens
    antimicrobials
    combinations
    Date
    29/06/2017
    
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    URI
    http://hdl.handle.net/11019/1503
    Citation
    Mathur H, Field D, Rea MC, Cotter PD, Hill C, Ross RP. Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective. Frontiers in Microbiology 2017;8(1205); doi 10.3389/fmicb.2017.01205
    Abstract
    The continuing emergence of multi-drug resistant pathogens has sparked an interest in seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such avenue. A number of studies have been conducted, involving combinations of bacteriocins with other antimicrobials, to circumvent the development of antimicrobial resistance and/or increase antimicrobial potency. Such bacteriocin-antimicrobial combinations could have tremendous value, in terms of reducing the likelihood of resistance development due to the involvement of two distinct mechanisms of antimicrobial action. Furthermore, antimicrobial synergistic interactions may also have potential financial implications in terms of decreasing the costs of treatment by reducing the concentration of an expensive antimicrobial and utilizing it in combination with an inexpensive one. In addition, combinatorial therapies with bacteriocins can broaden antimicrobial spectra and/or result in a reduction in the concentration of an antibiotic required for effective treatments to the extent that potentially toxic or adverse side effects can be reduced or eliminated. Here, we review studies in which bacteriocins were found to be effective in combination with other antimicrobials, with a view to targeting clinical and/or food-borne pathogens. Furthermore, we discuss some of the bottlenecks which are currently hindering the development of bacteriocins as viable therapeutic options, as well as addressing the need to exercise caution when attempting to predict clinical outcomes of bacteriocin-antimicrobial combinations.
    Funder
    Science Foundation Ireland
    Grant Number
    SFI/12/RC/2273
    ae974a485f413a2113503eed53cd6c53
    https://doi.org/10.3389/fmicb.2017.01205
    Scopus Count
    Collections
    Food Biosciences
    Food Biosciences
    Food Biosciences
    Food Biosciences

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