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    Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs

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    Author
    Horodyska, Justyna
    Hamill, Ruth cc
    Varley, Patrick F.
    Wimmers, Klaus
    Keyword
    Feed conversion efficiency
    pigs
    growth rate
    SNP
    Genome-wide association
    candidate genes
    Date
    12/06/2017
    
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    URI
    http://hdl.handle.net/11019/1517
    Citation
    Horodyska J, Hamill RM, Varley PF, Reyer H, Wimmers K (2017) Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs. PLoS ONE 12(6): e0173482. https://doi.org/10.1371/journal.pone.0173482
    Abstract
    Feed conversion efficiency is a measure of how well an animal converts feed into live weight and it is typically expressed as feed conversion ratio (FCR). FCR and related traits like growth rate (e.g. days to 110 kg—D110) are of high interest for animal breeders, farmers and society due to implications on animal performance, feeding costs and environmental sustainability. The objective of this study was to identify genomic regions associated with FCR and D110 in pigs. A total of 952 terminal line boars, showing an individual variation in FCR, were genotyped using 60K SNP-Chips. Markers were tested for associations with estimated breeding values (EBV) for FCR and D110. For FCR, the largest number of associated SNPs was located on chromosomes 4 (30 SNPs), 1 (25 SNPs), X (15 SNPs) and 6 (12 SNPs). The most prominent genomic regions for D110 were identified on chromosomes 15 (10 SNPs), 1 and 4 (both 9 SNPs). The most significantly associated SNPs for FCR and D110 mapped 129.8 Kb from METTL11B (chromosome 4) and 32Kb from MBD5 (chromosome 15), respectively. A list of positional genes, closest to significantly associated SNPs, was used to identify enriched pathways and biological functions related to the QTL for both traits. A number of candidate genes were significantly overrepresented in pathways of immune cell trafficking, lymphoid tissue structure, organ morphology, endocrine system function, lipid metabolism, and energy production. After resequencing the coding region of selected positional and functional candidate genes, six SNPs were genotyped in a subset of boars. SNPs in PRKDC, SELL, NR2E1 and AKRIC3 showed significant associations with EBVs for FCR/D110. The study revealed a number of chromosomal regions and candidate genes affecting FCR/D110 and pointed to corresponding biological pathways related to lipid metabolism, olfactory reception, and also immunological status.
    Funder
    European Union
    Grant Number
    311794
    ae974a485f413a2113503eed53cd6c53
    https://doi.org/10.1371/journal.pone.0173482
    Scopus Count
    Collections
    Pig Development
    Food Quality & Sensory Science
    Food Quality & Sensory Science

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