Show simple item record

dc.contributor.authorCorrochano, Alberto R.*
dc.contributor.authorBuckin, Vitaly*
dc.contributor.authorKelly, Philip*
dc.contributor.authorGiblin, Linda*
dc.identifier.citationAlberto R. Corrochano, Vitaly Buckin, Phil M. Kelly, Linda Giblin. Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways. Journal of Dairy Science, 2018, 101(6), 4747-4761. Doi:
dc.description.abstractOxidative stress contributes to cell injury and aggravates several chronic diseases. Dietary antioxidants help the body to fight against free radicals and, therefore, avoid or reduce oxidative stress. Recently, proteins from milk whey liquid have been described as antioxidants. This review summarizes the evidence that whey products exhibit radical scavenging activity and reducing power. It examines the processing and treatment attempts to increase the antioxidant bioactivity and identifies 1 enzyme, subtilisin, which consistently produces the most potent whey fractions. The review compares whey from different milk sources and puts whey proteins in the context of other known food antioxidants. However, for efficacy, the antioxidant activity of whey proteins must not only survive processing, but also upper gut transit and arrival in the bloodstream, if whey products are to promote antioxidant levels in target organs. Studies reveal that direct cell exposure to whey samples increases intracellular antioxidants such as glutathione. However, the physiological relevance of these in vitro assays is questionable, and evidence is conflicting from dietary intervention trials, with both rats and humans, that whey products can boost cellular antioxidant biomarkers.en_US
dc.description.sponsorshipThis work was supported by the Department of Agriculture, Food and the Marine (Dublin, Ireland; FIRM project 13 F 454-WheyGSH). A. R. Corrochano is in receipt of a Teagasc Walsh Fellowship.
dc.publisherElsevier for American Dairy Science Associationen_US
dc.relation.ispartofseriesJournal of Dairy Science;vol 101
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.subjectWhey productsen_US
dc.subjectWhey proteinsen_US
dc.subjectBioactive peptidesen_US
dc.subjectAntioxidant activityen_US
dc.subjectOxidative stressen_US
dc.titleInvited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathwaysen_US
dc.contributor.sponsorDepartment of Agriculture, Food and the Marine, Irelanden_US
dc.contributor.sponsorTeagasc Walsh Fellowship Programmeen_US
dc.contributor.sponsorGrantNumber13 F 454en_US
dc.contributor.sponsorGrrantNumber13 F 454-WheyGSHen_US

Files in this item

A R Corrochano JDS.pdf

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States