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dc.contributor.authorBouwman, Aniek C.*
dc.contributor.authorHayes, Ben J.*
dc.contributor.authorPurfield, Deirdre C*
dc.contributor.authorBerry, Donagh*
dc.contributor.authorChamberlain, Amanda J.
dc.contributor.authorHurtado Ponce, Carla
dc.contributor.authorSargolzaei, Mehdi
dc.contributor.authorSchenkel, Flavio S.
dc.contributor.authorSahana, Goutam
dc.contributor.authorGovignon-Gion, Armelle
dc.contributor.authorBoitard, Simon
dc.contributor.authorDolezal, Marlies
dc.contributor.authorPausch, Hubert
dc.contributor.authorBrondum, Rasmus F.
dc.contributor.authorBowman, Phil J.
dc.contributor.authorThomsen, Bo
dc.contributor.authorGuldbrandtsen, Bernt
dc.contributor.authorLund, Mogens S.
dc.contributor.authorServin, Bertrand
dc.contributor.authorGarrick, Dorian J.
dc.contributor.authorReecy, James
dc.contributor.authorVilkki, Johanna
dc.contributor.authorBagnato, Alessandro
dc.contributor.authorWang, Min
dc.contributor.authorHoff, Jesse L.
dc.contributor.authorSchnabel, Robert D.
dc.contributor.authorTaylor, Jeremy F.
dc.contributor.authorVinkhuyzen, Anna A. E.
dc.contributor.authorPanitz, Frank
dc.contributor.authorBendixen, Christian
dc.contributor.authorHolm, Lars-Erik
dc.contributor.authorGredler, Birgit
dc.contributor.authorHoze, Chris
dc.contributor.authorBoussaha, Mekki
dc.contributor.authorSanchez, Marie-Pierre
dc.contributor.authorRocha, Dominique
dc.contributor.authorCapitan, Aurelien
dc.contributor.authorTribout, Thierry
dc.contributor.authorBarbat, Anne
dc.contributor.authorCroiseau, Pascal
dc.contributor.authorDrogemuller, Cord
dc.contributor.authorJagannathan, Vidhya
dc.contributor.authorVander Jagt, Christy
dc.contributor.authorCrowley, John J.
dc.contributor.authorBieber, Anna
dc.contributor.authorEmmerling, Reiner
dc.contributor.authorGotz, Kay-Uwe
dc.contributor.authorFrischknecht, Mirjam
dc.contributor.authorRuss, Ingolf
dc.contributor.authorSolkner, Johann
dc.contributor.authorVan Tassell, Curtis P.
dc.contributor.authorFries, Ruedi
dc.contributor.authorStothard, Paul
dc.contributor.authorVeerkamp, Roel F.
dc.contributor.authorBoichard, Didier
dc.contributor.authorGoddard, Mike E.
dc.date.accessioned2018-08-16T14:34:43Z
dc.date.available2018-08-16T14:34:43Z
dc.date.issued2018-02-19
dc.identifier.citationBouwman AC, Daetwyler HD, Chamberlain AJ, Ponce CH, Sargolzaei M, Schenkel FS, Sahana G, Govignon-Gion A, Boitard S, Dolezal M and others. Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals. Nature Genetics 2018;50(3):362-367; doi 10.1038/s41588-018-0056-5en_US
dc.identifier.urihttp://hdl.handle.net/11019/1595
dc.descriptionpeer-revieweden_US
dc.descriptionH.D.D., A.J.C., P.J.B. and B.J.H. would like to acknowledge the Dairy Futures Cooperative Research Centre for funding. H.P. and R.F. acknowledge funding from the German Federal Ministry of Education and Research (BMBF) within the AgroClustEr ‘Synbreed—Synergistic Plant and Animal Breeding’ (grant 0315527B). H.P., R.F., R.E. and K.-U.G. acknowledge the Arbeitsgemeinschaft Süddeutscher Rinderzüchter, the Arbeitsgemeinschaft Österreichischer Fleckviehzüchter and ZuchtData EDV Dienstleistungen for providing genotype data. A. Bagnato acknowledges the European Union (EU) Collaborative Project LowInputBreeds (grant agreement 222623) for providing Brown Swiss genotypes. Braunvieh Schweiz is acknowledged for providing Brown Swiss phenotypes. H.P. and R.F. acknowledge the German Holstein Association (DHV) and the Confederación de Asociaciones de Frisona Española (CONCAFE) for sharing genotype data. H.P. was financially supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft (DFG) (grant PA 2789/1-1). D.B. and D.C.P. acknowledge funding from the Research Stimulus Fund (11/S/112) and Science Foundation Ireland (14/IA/2576). M.S. and F.S.S. acknowledge the Canadian Dairy Network (CDN) for providing the Holstein genotypes. P.S. acknowledges funding from the Genome Canada project entitled ‘Whole Genome Selection through Genome Wide Imputation in Beef Cattle’ and acknowledges WestGrid and Compute/Calcul Canada for providing computing resources. J.F.T. was supported by the National Institute of Food and Agriculture, US Department of Agriculture, under awards 2013-68004-20364 and 2015-67015-23183. A. Bagnato, F.P., M.D. and J.W. acknowledge EU Collaborative Project Quantomics (grant 516 agreement 222664) for providing Brown Swiss and Finnish Ayrshire sequences and genotypes. A.C.B. and R.F.V. acknowledge funding from the public–private partnership ‘Breed4Food’ (code BO-22.04-011- 001-ASG-LR) and EU FP7 IRSES SEQSEL (grant 317697). A.C.B. and R.F.V. acknowledge CRV (Arnhem, the Netherlands) for providing data on Dutch and New Zealand Holstein and Jersey bulls.en_US
dc.description.abstractStature is affected by many polymorphisms of small effect in humans1. In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10−8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP–seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofseriesNature Genetics;vol 50
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectCattle statureen_US
dc.subjectBody sizeen_US
dc.subjectgenome-wide association studiesen_US
dc.titleMeta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammalsen_US
dc.typeArticleen_US
dc.embargo.terms2018-08-19en_US
dc.identifier.doihttps://doi.org/10.1038/s41588-018-0056-5
dc.contributor.sponsorDepartment of Agriculture, Food and the Marine, Irelanden_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGerman Federal Ministry of Education and Researchen_US
dc.contributor.sponsorDeutsche Forschungsgemeinschaften_US
dc.contributor.sponsorBreed4Fooden_US
dc.contributor.sponsorEuropean Commissionen_US
dc.contributor.sponsorDairy Futures Cooperative Research Centreen_US
dc.contributor.sponsorGenome Canada projecten_US
dc.contributor.sponsorGrantNumber11/S/112
dc.contributor.sponsorGrantNumber14/IA/2576
dc.contributor.sponsorGrantNumber0315527B
dc.contributor.sponsorGrantNumberPA 2789/1-1
dc.contributor.sponsorGrantNumberBO-22.04-011-001-ASG-LR
dc.contributor.sponsorGrantNumber317697


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