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dc.contributor.authorKaliannan, Kanakaraju*
dc.contributor.authorRobertson, Ruairi C*
dc.contributor.authorMurphy, Kiera*
dc.contributor.authorSTANTON, CATHERINE*
dc.contributor.authorKang, Chao*
dc.contributor.authorWang, Bin*
dc.contributor.authorHao, Lei*
dc.contributor.authorBhan, Atul K*
dc.contributor.authorKang, Jing X*
dc.date.accessioned2018-12-07T12:28:55Z
dc.date.available2018-12-07T12:28:55Z
dc.date.issued2018-11-13
dc.identifier.citationKaliannan K, Robertson RC, Murphy K, Stanton C, Kang C, Wang B, Hao L, Bhan AK, Kang JX. Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice. Microbiome 2018;6(1):205; doi 10.1186/s40168-018-0587-0en_US
dc.identifier.urihttp://hdl.handle.net/11019/1639
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Understanding the mechanism of the sexual dimorphism in susceptibility to obesity and metabolic syndrome (MS) is important for the development of effective interventions for MS. Results Here we show that gut microbiome mediates the preventive effect of estrogen (17β-estradiol) on metabolic endotoxemia (ME) and low-grade chronic inflammation (LGCI), the underlying causes of MS and chronic diseases. The characteristic profiles of gut microbiome observed in female and 17β-estradiol-treated male and ovariectomized mice, such as decreased Proteobacteria and lipopolysaccharide biosynthesis, were associated with a lower susceptibility to ME, LGCI, and MS in these animals. Interestingly, fecal microbiota-transplant from male mice transferred the MS phenotype to female mice, while antibiotic treatment eliminated the sexual dimorphism in MS, suggesting a causative role of the gut microbiome in this condition. Moreover, estrogenic compounds such as isoflavones exerted microbiome-modulating effects similar to those of 17β-estradiol and reversed symptoms of MS in the male mice. Finally, both expression and activity of intestinal alkaline phosphatase (IAP), a gut microbiota-modifying non-classical anti-microbial peptide, were upregulated by 17β-estradiol and isoflavones, whereas inhibition of IAP induced ME and LGCI in female mice, indicating a critical role of IAP in mediating the effects of estrogen on these parameters. Conclusions In summary, we have identified a previously uncharacterized microbiome-based mechanism that sheds light upon sexual dimorphism in the incidence of MS and that suggests novel therapeutic targets and strategies for the management of obesity and MS in males and postmenopausal women.en_US
dc.language.isoenen_US
dc.publisherBiomed Centralen_US
dc.relation.ispartofseriesMicrobiome;
dc.subjectEstrogenen_US
dc.subjectGut microbiomeen_US
dc.subjectObesityen_US
dc.subjectMetabolic syndromeen_US
dc.subjectIsoflavonesen_US
dc.subjectChronic inflammationen_US
dc.titleEstrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in miceen_US
dc.typeArticleen_US
dc.date.updated2018-11-18T04:26:28Z
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.identifier.doihttps://doi.org/10.1186/s40168-018-0587-0
dc.contributor.sponsorSansun Life Sciencesen_US
dc.contributor.sponsorFortune Education Foundationen_US
refterms.dateFOA2018-12-07T12:28:55Z


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