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dc.contributor.authorNilaweera, Kanishka N.*
dc.contributor.authorSpeakman, J. R.*
dc.date.accessioned2018-12-11T10:21:36Z
dc.date.available2018-12-11T10:21:36Z
dc.date.issued2018-12-03
dc.identifier.citationNilaweera, K. N., and Speakman, J. R. (2018) Regulation of intestinal growth in response to variations in energy supply and demand. Obesity Reviews, 19: 61–72. https://doi.org/10.1111/obr.12780.en_US
dc.identifier.urihttp://hdl.handle.net/11019/1646
dc.descriptionpeer-revieweden_US
dc.description.abstractThe growth of the intestine requires energy, which is known to be met by catabolism of ingested nutrients. Paradoxically, during whole body energy deficit including calorie restriction, the intestine grows in size. To understand how and why this happens, we reviewed data from several animal models of energetic challenge. These were bariatric surgery, cold exposure, lactation, dietary whey protein intake and calorie restriction. Notably, these challenges all reduced the adipose tissue mass, altered hypothalamic neuropeptide expression and increased intestinal size. Based on these data, we propose that the loss of energy in the adipose tissue promotes the growth of the intestine via a signalling mechanism involving the hypothalamus. We discuss possible candidates in this pathway including data showing a correlative change in intestinal (ileal) expression of the cyclin D1 gene with adipose tissue mass, adipose derived‐hormone leptin and hypothalamic expression of leptin receptor and the pro‐opiomelanocortin gene. The ability of the intestine to grow in size during depletion of energy stores provides a mechanism to maximize assimilation of ingested energy and in turn sustain critical functions of tissues important for survival.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesObesity Reviews;
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectAdipose tissueen_US
dc.subjectHypothalamusen_US
dc.subjectIntestineen_US
dc.titleRegulation of intestinal growth in response to variations in energy supply and demanden_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1111/obr.12780
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorBiotechnology and Biological Sciences Research Council (BBSRC)en_US
dc.contributor.sponsorGrantNumberSFI/16/BBSRC/3389en_US
dc.contributor.sponsorGrantNumberBB/P009875/1en_US
refterms.dateFOA2018-12-11T10:21:36Z


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