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dc.contributor.authorFaraone, Immacolata
dc.contributor.authorRai, Dilip K.
dc.contributor.authorRusso, Daniela
dc.contributor.authorChiummiento, Lucia
dc.contributor.authorFernandez, Eloy
dc.contributor.authorChoudhary, Alka
dc.contributor.authorMilella, Luigi
dc.date.accessioned2019-12-05T10:10:44Z
dc.date.available2019-12-05T10:10:44Z
dc.date.issued2019-08-03
dc.identifier.citationFaraone, I.; Rai, D.K.; Russo, D.; Chiummiento, L.; Fernandez, E.; Choudhary, A.; Milella, L. Antioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile of Azorella glabra Wedd. Plants 2019, 8, 265. doi: https://dx.doi.org/10.3390/plants8080265en_US
dc.identifier.urihttp://hdl.handle.net/11019/1829
dc.descriptionpeer-revieweden_US
dc.descriptionSupplementary material available Table S1: LC-Q-Tof chromatograms showing the retention times of standard compounds mix used for the identification and quantification of various polyphenols and a terpene in the ethyl acetate fraction of Azorella glabra Wedd.
dc.description.abstractOxidative stress is involved in different diseases, such as diabetes and neurodegenerative diseases. The genus Azorella includes about 70 species of flowering plant species; most of them are commonly used as food and in particular as a tea infusion in the Andean region of South America in folk medicine to treat various chronic diseases. Azorella glabra Wedd. aerial parts were firstly analyzed for their in vitro antioxidant activity using different complementary assays. In particular, radical scavenging activity was tested against biological neutral radical DPPH; ferric reducing power and lipid peroxidation inhibitory capacity (FRAP and Beta-Carotene Bleaching tests) were also determined. The Relative Antioxidant Capacity Index (RACI) was used to compare data obtained by different assays. Then, the inhibitory ability of samples was investigated against α-amylase and α-glucosidase enzymes involved in diabetes and against acetylcholinesterase and butyrylcholinesterase enzymes considered as strategy for the treatment of Parkinson’s or Alzheimer’s diseases. Moreover, the phytochemical profile of the sample showing the highest RACI (1.35) and interesting enzymatic activities (IC50 of 163.54 ± 9.72 and 215.29 ± 17.10 μg/mL in α-glucosidase and acetylcholinesterase inhibition, respectively) was subjected to characterization and quantification of its phenolic composition using LC-MS/MS analysis. In fact, the ethyl acetate fraction derived from ethanol extract by liquid/liquid extraction showed 29 compounds, most of them are cinnamic acid derivatives, flavonoid derivatives, and a terpene. To the best of our knowledge, this is the first report about the evaluation of significant biological activities and phytochemical profile of A. glabra, an important source of health-promoting phytochemicals.en_US
dc.description.sponsorshipThis work was supported by the Regione Basilicata; the Fondazione Enrico Mattei DGR n. 1490 del 4/12/2014, vs. rep. n. 163 n8; and the Regional Project ALIMINTEGRA, GO NUTRIBAS financed on 16.1 PSR Basilicata founding ex D.G.R. No. 312/17 CUP: C31G18000210002.
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesPlants;Vol. 8 (8)
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectApiaceaeen_US
dc.subjectAzorella glabraen_US
dc.subjectDPPHen_US
dc.subjectBeta-Carotene Bleachingen_US
dc.subjectRACIen_US
dc.subjectphenolic characterizationen_US
dc.subjectUHPLC-MS/MSen_US
dc.subjectpolyphenolsen_US
dc.subjectflavonoidsen_US
dc.subjecthealth-promoting compoundsen_US
dc.titleAntioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile of Azorella glabra Wedden_US
dc.typeArticleen_US
dc.identifier.doihttps://dx.doi.org/10.3390/plants8080265
dc.contributor.sponsorRegione Basilicataen_US
dc.contributor.sponsorFondazione Enrico Mattei DGRen_US
dc.contributor.sponsorALIMINTEGRA, GO NUTRIBASen_US
dc.contributor.sponsorGrantNumber312/17 CUP: C31G18000210002
refterms.dateFOA2019-12-05T10:10:44Z


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