Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses
Author
García-Conesa, María-TeresaChambers, Karen
Combet, Emilie
Pinto, Paula
Garcia-Aloy, Mar
Andrés-Lacueva, Cristina
de Pascual-Teresa, Sonia
Mena, Pedro
Konic Ristic, Aleksandra
Hollands, Wendy
Kroon, Paul
Rodríguez-Mateos, Ana
Istas, Geoffrey
Kontogiorgis, Christos
Rai, Dilip K.
Gibney, Eileen
Morand, Christine
Espín, Juan
González-Sarrías, Antonio
Keyword
ellagitanninsanthocyanins
interindividual variability
meta-analysis
cardiometabolic disorders
pomegranate
nuts
berries
red wine
red grapes
Date
2018-02-28
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García-Conesa, M.-T.; Chambers, K.; Combet, E.; Pinto, P.; Garcia-Aloy, M.; Andrés-Lacueva, C.; De Pascual-Teresa, S.; Mena, P.; Konic Ristic, A.; Hollands, W.J.; Kroon, P.A.; Rodríguez-Mateos, A.; Istas, G.; Kontogiorgis, C.A.; Rai, D.K.; Gibney, E.R.; Morand, C.; Espín, J.C.; González-Sarrías, A. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses. Int. J. Mol. Sci. 2018, 19(3), 694. doi: https://dx.doi.org/10.3390/ijms19030694Abstract
Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.Funder
European Cooperation in Science and Technologyae974a485f413a2113503eed53cd6c53
https://dx.doi.org/10.3390/ijms19030694
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