Antioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile of Wedd.
Rai, Dilip K.
MetadataShow full item record
StatisticsDisplay Item Statistics
CitationFaraone, I.; Rai, D.K.; Russo, D.; Chiummiento, L.; Fernandez, E.; Choudhary, A.; Milella, L. Antioxidant, Antidiabetic, and Anticholinesterase Activities and Phytochemical Profile of Azorella glabra Wedd. Plants 2019, 8, 265.
AbstractOxidative stress is involved in different diseases, such as diabetes and neurodegenerative diseases. The genus Azorella includes about 70 species of flowering plant species; most of them are commonly used as food and in particular as a tea infusion in the Andean region of South America in folk medicine to treat various chronic diseases. Azorella glabra Wedd. aerial parts were firstly analyzed for their in vitro antioxidant activity using different complementary assays. In particular, radical scavenging activity was tested against biological neutral radical DPPH; ferric reducing power and lipid peroxidation inhibitory capacity (FRAP and Beta-Carotene Bleaching tests) were also determined. The Relative Antioxidant Capacity Index (RACI) was used to compare data obtained by different assays. Then, the inhibitory ability of samples was investigated against α-amylase and α-glucosidase enzymes involved in diabetes and against acetylcholinesterase and butyrylcholinesterase enzymes considered as strategy for the treatment of Parkinson's or Alzheimer's diseases. Moreover, the phytochemical profile of the sample showing the highest RACI (1.35) and interesting enzymatic activities (IC50 of 163.54 ± 9.72 and 215.29 ± 17.10 μg/mL in α-glucosidase and acetylcholinesterase inhibition, respectively) was subjected to characterization and quantification of its phenolic composition using LC-MS/MS analysis. In fact, the ethyl acetate fraction derived from ethanol extract by liquid/liquid extraction showed 29 compounds, most of them are cinnamic acid derivatives, flavonoid derivatives, and a terpene. To the best of our knowledge, this is the first report about the evaluation of significant biological activities and phytochemical profile of A. glabra, an important source of health-promoting phytochemicals.
FunderRegione Basilicata; Fondazione Enrico Mattei DGR; Regional Project ALIMINTEGRA, GO NUTRIBAS
Grant Number1490 del 4/12/2014; 312/17 CUP: C31G18000210002
The following license files are associated with this item:
- Creative Commons
- Phytochemicals of <i>Minthostachys diffusa</i> Epling and Their Health-Promoting Bioactivities.
- Authors: Faraone I, Russo D, Chiummiento L, Fernandez E, Choudhary A, Monné M, Milella L, Rai DK
- Issue date: 2020 Feb 1
- Antioxidant Activity and Phytochemical Characterization of <i>Senecio clivicolus</i> Wedd.
- Authors: Faraone I, Rai DK, Chiummiento L, Fernandez E, Choudhary A, Prinzo F, Milella L
- Issue date: 2018 Sep 29
- <i>A</i>dvances in <i>Azorella glabra</i> Wedd. Extract Research: In Vitro Antioxidant Activity, Antiproliferative Effects on Acute Myeloid Leukemia Cells and Bioactive Compound Characterization.
- Authors: Lamorte D, Faraone I, Laurenzana I, Trino S, Russo D, Rai DK, Armentano MF, Musto P, Sgambato A, De Luca L, Milella L, Caivano A
- Issue date: 2020 Oct 22
- Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles.
- Authors: Russo D, Valentão P, Andrade PB, Fernandez EC, Milella L
- Issue date: 2015 Jul 31
- Multidirectional insights into the biochemical and toxicological properties of Bougainvillea glabra (Choisy.) aerial parts: A functional approach for bioactive compounds.
- Authors: Saleem H, Zengin G, Ahmad I, Lee JTB, Htar TT, Mahomoodally FM, Naidu R, Ahemad N
- Issue date: 2019 Jun 5