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dc.contributor.authorMurphy, Kiera
dc.contributor.authorCurley, David
dc.contributor.authorO’Callaghan, Tom F.
dc.contributor.authorO’Shea, Carol A
dc.contributor.authorDempsey, Eugene
dc.contributor.authorO'Toole, Paul W.
dc.contributor.authorRoss, R Paul
dc.contributor.authorRyan, C. Anthony
dc.contributor.authorSTANTON, CATHERINE
dc.date.accessioned2020-02-13T15:42:05Z
dc.date.available2020-02-13T15:42:05Z
dc.date.issued2017-01-17
dc.identifier.citationMurphy, K., Curley, D., O’Callaghan, T. et al. The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study. Sci Rep 7, 40597 (2017). https://doi.org/10.1038/srep40597en_US
dc.identifier.urihttp://hdl.handle.net/11019/1860
dc.descriptionpeer-revieweden_US
dc.description.abstractHuman milk contains a diverse array of bioactives and is also a source of bacteria for the developing infant gut. The aim of this study was to characterize the bacterial communities in human milk and infant faeces over the first 3 months of life, in 10 mother-infant pairs. The presence of viable Bifidobacterium and Lactobacillus in human milk was also evaluated. MiSeq sequencing revealed a large diversity of the human milk microbiota, identifying over 207 bacterial genera in milk samples. The phyla Proteobacteria and Firmicutes and the genera Pseudomonas, Staphylococcus and Streptococcus were the predominant bacterial groups. A core of 12 genera represented 81% of the microbiota relative abundance in milk samples at week 1, 3 and 6, decreasing to 73% at week 12. Genera shared between infant faeces and human milk samples accounted for 70–88% of the total relative abundance in infant faecal samples, supporting the hypothesis of vertical transfer of bacteria from milk to the infant gut. In addition, identical strains of Bifidobacterium breve and Lactobacillus plantarum were isolated from the milk and faeces of one mother-infant pair. Vertical transfer of bacteria via breastfeeding may contribute to the initial establishment of the microbiota in the developing infant intestine.en_US
dc.language.isoenen_US
dc.publisherNatureen_US
dc.relation.ispartofseriesScientific Reports;vol 7
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectCompositionen_US
dc.subjectchild developmenten_US
dc.subjecthuman milken_US
dc.subjectBifidobacteriumen_US
dc.subjectLactobacillusen_US
dc.subjectmicrobiotaen_US
dc.subjectbreastfeedingen_US
dc.titleThe Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Studyen_US
dc.typeArticleen_US
dc.identifier.doihttps://dx.doi.org/10.1038/srep40597
dc.contributor.sponsorDepartment of Agriculture, Food and the Marineen_US
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGrantNumber10/RDT/MFRC/705en_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
refterms.dateFOA2020-02-13T15:42:05Z


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