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dc.contributor.authorMukiibi, Robert
dc.contributor.authorVinsky, Michael
dc.contributor.authorFitzsimmons, Carolyn
dc.contributor.authorStothard, Paul
dc.contributor.authorWaters, Sinéad M.
dc.contributor.authorLi, Changxi
dc.contributor.authorKeogh, Kate
dc.date.accessioned2020-02-13T16:00:56Z
dc.date.available2020-02-13T16:00:56Z
dc.date.issued2018-05-08
dc.identifier.citationMukiibi, R., Vinsky, M., Keogh, K.A. et al. Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle. Sci Rep 8, 7303 (2018). https://doi.org/10.1038/s41598-018-25605-3en_US
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11019/1863
dc.descriptionpeer-revieweden_US
dc.description.abstractThe genetic mechanisms controlling residual feed intake (RFI) in beef cattle are still largely unknown. Here we performed whole transcriptome analyses to identify differentially expressed (DE) genes and their functional roles in liver tissues between six extreme high and six extreme low RFI steers from three beef breed populations including Angus, Charolais, and Kinsella Composite (KC). On average, the next generation sequencing yielded 34 million single-end reads per sample, of which 87% were uniquely mapped to the bovine reference genome. At false discovery rate (FDR) < 0.05 and fold change (FC) > 2, 72, 41, and 175 DE genes were identified in Angus, Charolais, and KC, respectively. Most of the DE genes were breed-specific, while five genes including TP53INP1, LURAP1L, SCD, LPIN1, and ENSBTAG00000047029 were common across the three breeds, with TP53INP1, LURAP1L, SCD, and LPIN1 being downregulated in low RFI steers of all three breeds. The DE genes are mainly involved in lipid, amino acid and carbohydrate metabolism, energy production, molecular transport, small molecule biochemistry, cellular development, and cell death and survival. Furthermore, our differential gene expression results suggest reduced hepatic lipid synthesis and accumulation processes in more feed efficient beef cattle of all three studied breeds.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofseriesScientific Reports;vol 8
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectbeef cattleen_US
dc.subjectresidual feed intakeen_US
dc.subjectlipiden_US
dc.subjecttranscriptomeen_US
dc.subjectgeneticsen_US
dc.subjectgenomeen_US
dc.titleTranscriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattleen_US
dc.typeArticleen_US
dc.identifier.doihttps://dx.doi.org/10.1038/s41598-018-25605-3
dc.contributor.sponsorAlberta Livestock and Meat Agencyen_US
dc.contributor.sponsorAlberta Agriculture and Forestryen_US
dc.contributor.sponsorTeagasc Walsh Fellowship Programmeen_US
dc.contributor.sponsorUniversity of Albertaen_US
dc.contributor.sponsorGrantNumber2014F047Ren_US
dc.contributor.sponsorGrantNumberJ-001274en_US
dc.source.volume8
dc.source.issue1
refterms.dateFOA2020-02-13T16:00:56Z


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