Show simple item record

dc.contributor.authorO’Donovan, Ciara M.
dc.contributor.authorMadigan, Sharon M.
dc.contributor.authorGarcia-Perez, Isabel
dc.contributor.authorRankin, Alan
dc.contributor.authorO’ Sullivan, Orla
dc.contributor.authorCotter, Paul D.
dc.date.accessioned2020-06-03T15:19:48Z
dc.date.available2020-06-03T15:19:48Z
dc.date.issued2019-09-18
dc.identifier.citationO’Donovan, C., Madigan, S., Garcia-Perez, I., Rankin, A., O’ Sullivan, O. and Cotter, P. Distinct microbiome composition and metabolome exists across subgroups of elite Irish athletes. Journal of Science and Medicine in Sport. 2019, doi: https://doi.org/10.1016/j.jsams.2019.08.290en_US
dc.identifier.issn1440-2440
dc.identifier.urihttp://hdl.handle.net/11019/1922
dc.descriptionpeer-revieweden_US
dc.description.abstractObjectives: The gut microbiome has begun to be characterised in athlete groups, albeit, to date, only across a subset of sports. This study aimed to determine if the gut microbiome and metabolome differed across sports classification groups (SCGs) among elite Irish athletes, many of whom were participating in the 2016 Summer Olympics. Methods: Faecal and urine samples were collected from 37 international level athletes. Faecal samples were prepared for shotgun metagenomic sequencing and faecal and urine samples underwent metabolomic profiling. Results: Differences were observed in the composition and functional capacity of the gut microbiome of athletes across SCGs. The microbiomes of athletes participating in sports with a high dynamic component were the most distinct compositionally (greater differences in proportions of species), while those of athletes participating in sports with high dynamic and static components were the most functionally distinct (greater differences in functional potential). Additionally, both microbial (faecal) and human (urine) derived metabolites were found to vary between SCGs. In particular cis-aconitate, succinic acid and lactate, in urine samples, and creatinine, in faeces, were found to be significantly different between groups. These differences were evident despite the absence of significant differences in diet, as determined using food frequency questionnaires, which were translated into nutrient intake values using FETA. Conclusions: Differences in the gut microbiome and metabolome between groups, in the absence of dietary changes, indicates a role for training load or type as a contributory factor. Further exploration of this hypothesis has the potential to benefit athletes, aspiring athletes and the general public.en_US
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.relation.ispartofseriesJournal of Science and Medicine in Sport;
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectGut microbiomeen_US
dc.subjectAthletesen_US
dc.subjectMetabolomeen_US
dc.subjectFitnessen_US
dc.subjectOlympicsen_US
dc.subjectExerciseen_US
dc.titleDistinct microbiome composition and metabolome exists across subgroups of elite Irish athletesen_US
dc.typeArticleen_US
dc.embargo.terms2021-09-18en_US
dc.identifier.doihttps://doi.org/10.1016/j.jsams.2019.08.290
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorNational Institute for Health Researchen_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.contributor.sponsorGrantNumber13/SIRG/2160en_US
dc.contributor.sponsorGrantNumber11/PI/1137.en_US
dc.contributor.sponsorGrantNumberNIHR-CDF-2017-10-032en_US


Files in this item

Thumbnail
Name:
Distinct-microbiome-compositio ...
Size:
1.502Mb
Format:
PDF
Description:
main article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States