Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice.
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CitationSu, H., Chen, J., Miao, S., Deng, K., Liu, J., Zeng, S., Zheng, B. and Lu, X. Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice. Food and Chemical Toxicology, 2019, 110838. doi: https://doi.org/10.1016/j.fct.2019.110838
AbstractThe aim of this study was to evaluate the effects of lotus seed oligosaccharides (formulation consisting of LSO2, LSO3-1, LSO3-2 and LSO4; relative ratios are 1.107:0.554: 0.183:0.443, m/m/m/m) at dosages of 0.42, 0.83 g/d/kg bw and 2.49 g/d/kg bw on the microbiota composition and the propulsion of intestinal contents in the gut of mice. The results showed that fecal water content increased in treated mice; there was less gut microbiota diversity than in other groups; and there was a large number of fauna in the cecum of the mice. At the same time, the number of short-chain fatty acid (SCFA) bacterial producers increased after feeding with oligosaccharides; Lotus seed oligosaccharides (LOS) also enhanced the concentration of SCFAs in the intestine, which also increased the concentration of cytokines in the serum of mice. In conclusion, these findings suggest that LOS or combination with resistant starch has a better effect on relieving constipation.
FunderChina-Ireland International Cooperation Centre; National Natural Science Foundation of China; Fujian Agriculture and Forestry University; Higher Education of China; Department of Education of Fujian; Science and Technology Major Project, Fujian Province; Natural Science Foundation of Fujian Province; Scientific and Technological Development, FAFU
Grant NumberKXGH17001; 31601473; xjq201811; 108/k41mke02a; JK2015012; 2018NZ0003-1; 2018J01697; CXZX2018069
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