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dc.contributor.authorSu, Han
dc.contributor.authorChen, Jinghao
dc.contributor.authorMiao, Song
dc.contributor.authorDeng, Kaibo
dc.contributor.authorLiu, Jiawen
dc.contributor.authorZeng, Shaoxiao
dc.contributor.authorZheng, Baodong
dc.contributor.authorLu, Xu
dc.date.accessioned2020-06-15T11:59:25Z
dc.date.available2020-06-15T11:59:25Z
dc.date.issued2019-09-27
dc.identifier.citationSu, H., Chen, J., Miao, S., Deng, K., Liu, J., Zeng, S., Zheng, B. and Lu, X. Lotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice. Food and Chemical Toxicology, 2019, 110838. doi: https://doi.org/10.1016/j.fct.2019.110838en_US
dc.identifier.issn1873-6351
dc.identifier.urihttp://hdl.handle.net/11019/1973
dc.descriptionpre-printen_US
dc.description.abstractThe aim of this study was to evaluate the effects of lotus seed oligosaccharides (formulation consisting of LSO2, LSO3-1, LSO3-2 and LSO4; relative ratios are 1.107:0.554: 0.183:0.443, m/m/m/m) at dosages of 0.42, 0.83 g/d/kg bw and 2.49 g/d/kg bw on the microbiota composition and the propulsion of intestinal contents in the gut of mice. The results showed that fecal water content increased in treated mice; there was less gut microbiota diversity than in other groups; and there was a large number of fauna in the cecum of the mice. At the same time, the number of short-chain fatty acid (SCFA) bacterial producers increased after feeding with oligosaccharides; Lotus seed oligosaccharides (LOS) also enhanced the concentration of SCFAs in the intestine, which also increased the concentration of cytokines in the serum of mice. In conclusion, these findings suggest that LOS or combination with resistant starch has a better effect on relieving constipation.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesFood and Chemical Toxicology;
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectGut microbiotaen_US
dc.subjectLotus seedsen_US
dc.subjectOligosaccharidesen_US
dc.subjectPrebioticsen_US
dc.subjectResistant starchen_US
dc.subjectShort-chain fatty acidsen_US
dc.titleLotus seed oligosaccharides at various dosages with prebiotic activity regulate gut microbiota and relieve constipation in mice.en_US
dc.typeArticleen_US
dc.embargo.terms2020-09-27en_US
dc.identifier.doihttps://doi.org/10.1016/j.fct.2019.110838
dc.contributor.sponsorChina-Ireland International Cooperation Centreen_US
dc.contributor.sponsorNational Natural Science Foundation of Chinaen_US
dc.contributor.sponsorFujian Agriculture and Forestry Universityen_US
dc.contributor.sponsorHigher Education of Chinaen_US
dc.contributor.sponsorDepartment of Education of Fujianen_US
dc.contributor.sponsorScience and Technology Major Project, Fujian Provinceen_US
dc.contributor.sponsorNatural Science Foundation of Fujian Provinceen_US
dc.contributor.sponsorScientific and Technological Development, FAFUen_US
dc.contributor.sponsorGrantNumberKXGH17001en_US
dc.contributor.sponsorGrantNumber31601473en_US
dc.contributor.sponsorGrantNumberxjq201811en_US
dc.contributor.sponsorGrantNumber108/k41mke02aen_US
dc.contributor.sponsorGrantNumberJK2015012en_US
dc.contributor.sponsorGrantNumber2018NZ0003-1en_US
dc.contributor.sponsorGrantNumber2018J01697en_US
dc.contributor.sponsorGrantNumberCXZX2018069en_US
dc.source.journaltitleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association


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