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    Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa

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    Author
    Zhou, Xingya
    Yang, Bo
    STANTON, CATHERINE cc
    Ross, R Paul
    Zhao, Jianxin
    Zhang, Hao
    Chen, Wei
    Keyword
    Lactobacillus paragasseri
    Lactobacillus gasseri
    Pan/core-genome
    ANI
    Genotype
    Date
    2020-02-03
    
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    URI
    http://hdl.handle.net/11019/2151
    Citation
    Zhou, X., Yang, B., Stanton, C. et al. Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa. BMC Genomics 21, 119 (2020). https://doi.org/10.1186/s12864-020-6527-y
    Abstract
    Background Lactobacillus gasseri as a probiotic has history of safe consumption is prevalent in infants and adults gut microbiota to maintain gut homeostasis. Results In this study, to explore the genomic diversity and mine potential probiotic characteristics of L. gasseri, 92 strains of L. gasseri were isolated from Chinese human feces and identified based on 16 s rDNA sequencing, after draft genomes sequencing, further average nucleotide identity (ANI) value and phylogenetic analysis reclassified them as L. paragasseri (n = 79) and L. gasseri (n = 13), respectively. Their pan/core-genomes were determined, revealing that L. paragasseri had an open pan-genome. Comparative analysis was carried out to identify genetic features, and the results indicated that 39 strains of L. paragasseri harboured Type II-A CRISPR-Cas system while 12 strains of L. gasseri contained Type I-E and II-A CRISPR-Cas systems. Bacteriocin operons and the number of carbohydrate-active enzymes were significantly different between the two species. Conclusions This is the first time to study pan/core-genome of L. gasseri and L. paragasseri, and compare their genetic diversity, and all the results provided better understating on genetics of the two species.
    Funder
    National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; National Firs-Class Discipline Program of Food Science and Technology; Jiangsu Province “Collaborative Innovation Center for Food Safety and Quality Control”
    Grant Number
    31530056; 31820103010; 31801521; JUSRP11733; JUFSTR20180102
    ae974a485f413a2113503eed53cd6c53
    https://doi.org/10.1186/s12864-020-6527-y
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    Teagasc publications in Biomed Central

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