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dc.contributor.authorZhou, Xingya
dc.contributor.authorYang, Bo
dc.contributor.authorSTANTON, CATHERINE
dc.contributor.authorRoss, R Paul
dc.contributor.authorZhao, Jianxin
dc.contributor.authorZhang, Hao
dc.contributor.authorChen, Wei
dc.date.accessioned2020-07-03T15:01:52Z
dc.date.available2020-07-03T15:01:52Z
dc.date.issued2020-02-03
dc.identifier.citationZhou, X., Yang, B., Stanton, C. et al. Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa. BMC Genomics 21, 119 (2020). https://doi.org/10.1186/s12864-020-6527-yen_US
dc.identifier.issn1471-2164
dc.identifier.urihttp://hdl.handle.net/11019/2151
dc.descriptionpeer-revieweden_US
dc.description.abstractBackground Lactobacillus gasseri as a probiotic has history of safe consumption is prevalent in infants and adults gut microbiota to maintain gut homeostasis. Results In this study, to explore the genomic diversity and mine potential probiotic characteristics of L. gasseri, 92 strains of L. gasseri were isolated from Chinese human feces and identified based on 16 s rDNA sequencing, after draft genomes sequencing, further average nucleotide identity (ANI) value and phylogenetic analysis reclassified them as L. paragasseri (n = 79) and L. gasseri (n = 13), respectively. Their pan/core-genomes were determined, revealing that L. paragasseri had an open pan-genome. Comparative analysis was carried out to identify genetic features, and the results indicated that 39 strains of L. paragasseri harboured Type II-A CRISPR-Cas system while 12 strains of L. gasseri contained Type I-E and II-A CRISPR-Cas systems. Bacteriocin operons and the number of carbohydrate-active enzymes were significantly different between the two species. Conclusions This is the first time to study pan/core-genome of L. gasseri and L. paragasseri, and compare their genetic diversity, and all the results provided better understating on genetics of the two species.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofseriesBMC Genomics;
dc.subjectLactobacillus paragasserien_US
dc.subjectLactobacillus gasserien_US
dc.subjectPan/core-genomeen_US
dc.subjectANIen_US
dc.subjectGenotypeen_US
dc.titleComparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxaen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1186/s12864-020-6527-y
dc.contributor.sponsorNational Natural Science Foundation of Chinaen_US
dc.contributor.sponsorFundamental Research Funds for the Central Universitiesen_US
dc.contributor.sponsorNational Firs-Class Discipline Program of Food Science and Technologyen_US
dc.contributor.sponsorJiangsu Province “Collaborative Innovation Center for Food Safety and Quality Control”en_US
dc.contributor.sponsorGrantNumber31530056en_US
dc.contributor.sponsorGrantNumber31820103010en_US
dc.contributor.sponsorGrantNumber31801521en_US
dc.contributor.sponsorGrantNumberJUSRP11733en_US
dc.contributor.sponsorGrantNumberJUFSTR20180102en_US
dc.source.volume21
dc.source.issue1
refterms.dateFOA2020-07-03T15:01:53Z


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