Show simple item record

dc.contributor.authorLawrence, Garreth W.
dc.contributor.authorBegley, Máire
dc.contributor.authorCotter, Paul D.
dc.contributor.authorGuinane, Caitriona M.
dc.date.accessioned2020-07-24T15:47:19Z
dc.date.available2020-07-24T15:47:19Z
dc.date.issued2020-01-30
dc.identifier.citationLawrence, G.W.; Begley, M.; Cotter, P.D.; Guinane, C.M. Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa. Int. J. Mol. Sci. 2020, 21, 924. https://doi.org/10.3390/ijms21030924en_US
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11019/2179
dc.descriptionpeer-revieweden_US
dc.description.abstractThe role of the gut microbiome in human health and disease is the focus of much attention. It has been widely agreed upon that our gut bacteria play a role in host immunity, nutrient absorption, digestion, metabolism, and other key drivers of health. Furthermore, certain microbial signatures and specific taxa have also been associated with the development of diseases, such as obesity; inflammatory bowel disease; and, indeed, colorectal cancer (CRC), which is the focus of this review. By extension, such taxa represent potential therapeutic targets. In particular, the emerging human pathogen Fusobacterium nucleatum represents an important agent in CRC development and its control within the gastrointestinal tract is desirable. This paper reviews the principal bacterial pathogens that have been associated with CRC to date and discusses the in vitro and human studies that have shown the potential use of biotherapeutic strains as a means of targeting CRC-associated bacteria.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMolecular Sciences;21
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectcolorectal canceren_US
dc.subjectmicrobiotaen_US
dc.subjectFusobacterium nucleatumen_US
dc.subjectprobioticsen_US
dc.subjectbiotherapeuticsen_US
dc.titlePotential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxaen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/ijms21030924
dc.source.volume21
dc.source.issue3
dc.source.beginpage924
refterms.dateFOA2020-07-24T15:47:19Z


Files in this item

Thumbnail
Name:
ijms-21-00924-v2.pdf
Size:
1.159Mb
Format:
PDF
Description:
main article

This item appears in the following Collection(s)

Show simple item record

Attribution-ShareAlike 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-ShareAlike 3.0 United States