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dc.contributor.authorReyer, Henry
dc.contributor.authorOster, Michael
dc.contributor.authorMcCormack, Ursula M.
dc.contributor.authorMuráni, Eduard
dc.contributor.authorGardiner, Gillian E.
dc.contributor.authorPonsuksili, Siriluck
dc.contributor.authorLawlor, Peadar G.
dc.contributor.authorWimmers, Klaus
dc.date.accessioned2020-07-24T15:49:03Z
dc.date.available2020-07-24T15:49:03Z
dc.date.issued2020-04-14
dc.identifier.citationReyer, H.; Oster, M.; McCormack, U.M.; Muráni, E.; Gardiner, G.E.; Ponsuksili, S.; Lawlor, P.G.; Wimmers, K. Host-Microbiota Interactions in Ileum and Caecum of Pigs Divergent in Feed Efficiency Contribute to Nutrient Utilization. Microorganisms 2020, 8, 563. https://doi.org/10.3390/microorganisms8040563en_US
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/11019/2180
dc.descriptionpeer-revieweden_US
dc.description.abstractThe composition of the intestinal microbiota plays an important role in the digestion and utilization of nutrients and for gut health. Low-fiber diets stimulate digestion and absorption processes, predominantly in the upper region of the gastrointestinal tract, thereby increasing the conversion of feed into body weight. As a consequence, the chemical composition of digesta after duodenal and jejunal absorption processes and passage has a limited complexity affecting colonization and molecular profiles of enterocytes in the hind gut. To decipher ileal and caecal microbial ecosystems and host transcriptional profiles that are beneficial for effective use of the remaining nutrients, pigs differing in feeding efficiency were studied. Biological functions that were consistently enriched at both the gene and microbiota levels comprise immunity-related processes, which ensure the integrity of the gastrointestinal tract. In addition, the differential abundance of certain genera, including Rothia, Subdoligranulu, Leeia and Cellulosilyticum, reflects the establishment of a microbial profile that supports the digestion of endogenously indigestible dietary components in highly feed-efficient pigs. Overall, the results indicate the potential to promote these beneficial functions and further improve feed efficiency through manipulation of dietary and probiotic strategies.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMicroorganisms;8
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectresidual feed intakeen_US
dc.subjectgene expressionen_US
dc.subjectcaecumen_US
dc.subjectileumen_US
dc.titleHost-Microbiota Interactions in Ileum and Caecum of Pigs Divergent in Feed Efficiency Contribute to Nutrient Utilizationen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3390/microorganisms8040563
dc.contributor.sponsorEuropean Unionen_US
dc.contributor.sponsorGrantNumber311794en_US
dc.source.volume8
dc.source.issue4
dc.source.beginpage563
refterms.dateFOA2020-07-24T15:49:04Z


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