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dc.contributor.authorO'Sullivan, Julie N
dc.contributor.authorRea, Mary C
dc.contributor.authorO'Connor, Paula M
dc.contributor.authorHill, Colin
dc.contributor.authorRoss, R Paul
dc.date.accessioned2020-07-31T11:38:41Z
dc.date.available2020-07-31T11:38:41Z
dc.date.issued2018-12-24
dc.identifier.citationO'Sullivan, J; Rea, M; O'Connor, P; Hill, C; Ross, P. Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens, FEMS Microbiology Ecology, Volume 95, Issue 2, February 2019, fiy241, https://doi.org/10.1093/femsec/fiy241en_US
dc.identifier.issn1574-6941
dc.identifier.urihttp://hdl.handle.net/11019/2215
dc.descriptionpeer-revieweden_US
dc.description.abstractThe demand for novel antimicrobial therapies due to the threat posed by antimicrobial resistance has resulted in a growing interest in the protective role of our skin bacteria and the importance of competition among bacteria on the skin. A survey of the cultivable bacteria on human skin was undertaken to identify the capacity of the skin microbiota to produce bacteriocins with activity against skin pathogens. Twenty-one bacteriocins produced by bacteria isolated from seven sites on the human body of each subject exhibited inhibition spectra ranging from broad to narrow range, inhibiting many Gram-positive bacteria, including opportunistic skin pathogens such as Propionibacterium acnes (recently renamed Cutibacterium acnes), Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus (MRSA). Sequencing indicated that the antimicrobial-producing isolates were predominately species/strains of the Staphylococcus genus. Colony mass spectrometry revealed peptide masses that do not correspond to known bacteriocins. In an era where antibiotic resistance is of major concern, the inhibitory effect of novel bacteriocins from the bacteria of skin origin demonstrates the antimicrobial potential that could be harnessed from within the human skin microbiota.en_US
dc.language.isoenen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofseriesFEMS Microbiologu Ecology;95
dc.rightsAttribution-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/3.0/us/*
dc.subjectskin pathogensen_US
dc.subjectstaphylococcien_US
dc.subjectantimicrobial potentialen_US
dc.subjectbacteriocinen_US
dc.subjectskin microbiotaen_US
dc.subjectskin microbiomeen_US
dc.titleHuman skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogensen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1093/femsec/fiy241
dc.contributor.sponsorScience Foundation Irelanden_US
dc.contributor.sponsorGrantNumberSFI/12/RC/2273en_US
dc.source.volume95
dc.source.issue2
refterms.dateFOA2020-07-31T11:38:42Z


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